HUMHBB
Example
HUMHBB, an example entry from `Genbank'. The DNA sequence proper starts about half way through the file after the bibliographic entries and annotations. As of 1998 this is no longer considered a particularly long sequence, with some complete chromosomes, ~1 million base-pairs, having been sequenced for other organisms. As of June 2000, a preliminary map of the entire human genome had been produced.
LOCUS HUMHBB 73326 bp ds-DNA PRI 10-OCT-1991
DEFINITION Human beta globin region on chromosome 11.
ACCESSION J00179 J00093 J00094 J00096 J00158 J00159 J00160 J00161 J00162
J00163 J00164 J00165 J00166 J00167 J00168 J00169 J00170 J00171
J00172 J00173 J00174 J00175 J00177 J00178 K01239 K01890 K02544
M18047 M19067 M24868 M24886 X00423 X00424 X00672
KEYWORDS Alu repetitive element; HPFH; KpnI repetitive sequence;
RNA polymerase III; allelic variation; alternate cap site;
beta-1 pseudogene; beta-globin; delta-globin; epsilon-globin;
gamma-globin; gene duplication; globin; polymorphism;
promoter mutation; pseudogene; repetitive sequence; thalassemia.
SOURCE Human mRNA, cDNA and DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 62427 to 62649; 63500 to 63628)
AUTHORS Marotta,C.A., Forget,B.G., Weissman,S.M., Verma,I.M.,
McCaffrey,R.P. and Baltimore,D.
TITLE Nucleotide sequences of human globin messenger RNA
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 71, 2300-2304 (1974)
STANDARD full staff_review
REFERENCE 2 (bases 63620 to 63664)
AUTHORS Forget,B.G., Marotta,C.A., Weissman,S.M. and Cohen-Solal,M.
TITLE Nucleotide sequences of the 3'-terminal untranslated region of
messenger RNA for human beta globin chain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 72, 3614-3618 (1975)
STANDARD full staff_review
REFERENCE 3 (bases 63611 to 63644)
AUTHORS Proudfoot,N.J. and Brownlee,G.G.
TITLE Nucleotide sequences of globin messenger RNA
JOURNAL Br. Med. Bull. 32, 251-256 (1976)
STANDARD simple staff_entry
REFERENCE 4 (bases 63691 to 63761)
AUTHORS Proudfoot,N.J. and Longley,J.I.
TITLE The 3' terminal sequences of human alpha and beta globin messenger
RNAs: Comparison with rabbit globin messenger RNA
JOURNAL Cell 9, 733-746 (1976)
STANDARD full staff_review
REFERENCE 5 (sites)
AUTHORS Proudfoot,N.J. and Brownlee,G.G.
TITLE Non-coding region sequences in eukaryotic messenger RNA
JOURNAL Nature 263, 211-214 (1976)
STANDARD full staff_review
REFERENCE 6 (bases 63614 to 63761)
AUTHORS Proudfoot,N.J.
TITLE Complete 3' noncoding region sequences of rabbit and human
beta-globin messenger RNA's
JOURNAL Cell 10, 559-570 (1977)
STANDARD full staff_review
REFERENCE 7 (bases 62155 to 62211)
AUTHORS Baralle,F.E.
TITLE Complete nucleotide sequence of the 5' noncoding region of human
alpha- and beta-globin mRNA
JOURNAL Cell 12, 1085-1095 (1977)
STANDARD full staff_review
REFERENCE 8 (sites)
AUTHORS Marotta,C.A., Forget,B.G., Cohen-Solal,M., Wilson,J.T. and
Weissman,S.M.
TITLE Human beta-globin messenger RNA: I. Nucleotide sequences derived
from complementary RNA
JOURNAL J. Biol. Chem. 252, 5019-5031 (1977)
STANDARD full staff_review
REFERENCE 9 (bases 62205 to 63628)
AUTHORS Cohen-Solal,M., Forget,B.G., Prensky,W., Marotta,C.A. and
Weissman,S.M.
TITLE Human beta-globin messenger RNA: II. Nucleotide sequences derived
from 125-I-labeled globin messenger RNA
JOURNAL J. Biol. Chem. 252, 5032-5039 (1977)
STANDARD full staff_review
REFERENCE 10 (bases 54808 to 54899; 62427 to 62649; 63500 to 63733)
AUTHORS Marotta,C.A., Wilson,J.T., Forget,B.G. and Weissman,S.M.
TITLE Human beta-globin messenger RNA. III. Nucleotide sequences derived
from complementary DNA
JOURNAL J. Biol. Chem. 252, 5040-5053 (1977)
STANDARD full staff_review
REFERENCE 11 (bases 62155 to 62207)
AUTHORS Chang,J.C., Temple,G.F., Poon,R., Neumann,K.H. and Kan,Y.W.
TITLE The nucleotide sequences of the untranslated 5' regions of human
alpha- and beta-globin mRNAs
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 74, 5145-5149 (1977)
STANDARD full staff_review
REFERENCE 12 (bases 56121 to 56202)
AUTHORS Lawn,R.M., Fritsch,E.F., Parker,R.C., Blake,G. and Maniatis,T.
TITLE The isolation and characterization of linked delta- and beta-
globin genes from a library of human DNA
JOURNAL Cell 15, 1157-1174 (1978)
STANDARD full staff_review
REFERENCE 13 (bases 35872 to 35964; 63500 to 63549)
AUTHORS Little,P., Curtis,P., Coutelle,C., Van Den Berg,J., Dalgleish,R.,
Malcolm,S., Courtney,M., Westaway,D. and Williamson,R.
TITLE Isolation and partial sequence of recombinant plasmids containing
human alpha-, beta- and gamma-globin cDNA fragments
JOURNAL Nature 273, 640-643 (1978)
STANDARD full staff_review
REFERENCE 14 (bases 62205 to 63760)
AUTHORS Wilson,J.T., Wilson,L.B., DeRiel,J.K., Villa-Komaroff,L.,
Efstratiadis,A., Forget,B.G. and Weissman,S.M.
TITLE Insertion of synthetic copies of human globin genes into bacterial
plasmids
JOURNAL Nucleic Acids Res. 5, 563-581 (1978)
STANDARD full staff_review
REFERENCE 15 (bases 34496 to 34581; 39432 to 39517)
AUTHORS Chang,J.C., Poon,R., Neumann,K.H. and Kan,Y.W.
TITLE The nucleotide sequence of the 5' untranslated region of human
gamma-globin mRNA
JOURNAL Nucleic Acids Res. 5, 3515-3522 (1978)
STANDARD full staff_review
REFERENCE 16 (bases 40857 to 41003)
AUTHORS Poon,R., Wai,K. and Boyer,H.W.
TITLE Sequence of the 3' noncoding and adjacent regions of human
gamma-globin mRNA
JOURNAL Nucleic Acids Res. 5, 4625-4630 (1978)
STANDARD full staff_review
REFERENCE 17 (bases 35844 to 35925; 40760 to 40841)
AUTHORS Smithies,O., Blechl,A.E., Denniston-Thompson,K., Newell,N.,
Richards,J.E., Slightom,J.L., Tucker,P.W. and Blattner,F.R.
TITLE Cloning human fetal gamma globin and mouse alpha-type globin DNA:
Characterization and partial sequencing
JOURNAL Science 202, 1284-1289 (1978)
STANDARD full staff_review
REFERENCE 18 (bases 34496 to 34554; 62155 to 62210; 63626 to 63760)
AUTHORS Kan,Y.W., Chang,C.S. and Poon,R.
TITLE Nucleotide sequences of the untranslated 5' and 3' regions of human
alpha-, beta-, and gamma-globin mRNAS
JOURNAL (in) Stamatoyannopoulos,G. and Newhouse,A.W. (Eds.);
Cellular and Molecular regulation of hemoglobin switching: 0-0,
Grune and Stratton, New York (1979)
STANDARD simple staff_entry
REFERENCE 19 (sites)
AUTHORS Chang,J.C. and Kan,Y.W.
TITLE Beta-0 thalassemia, a nonsense mutation in man
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 76, 2886-2889 (1979)
STANDARD full staff_review
REFERENCE 20 (bases 19864 to 19983)
AUTHORS Proudfoot,N.J. and Baralle,F.E.
TITLE Molecular cloning of human epsilon-globin gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 76, 5435-5439 (1979)
STANDARD full staff_review
REFERENCE 21 (sites)
AUTHORS Chang,J.C., Kan,Y.W., Trecartin,R.F. and Temple,G.F.
TITLE Nonsense mutation as a cause of beta-0 thalassemia
JOURNAL Ann. N.Y. Acad. Sci. 344, 113-119 (1980)
STANDARD full staff_review
REFERENCE 22 (sites)
AUTHORS Fritsch,E.F., Lawn,R.M. and Maniatis,T.
TITLE Molecular cloning and characterization of the human beta-like
globin gene cluster
JOURNAL Cell 19, 959-972 (1980)
STANDARD full staff_review
REFERENCE 23 (bases 19480 to 21759)
AUTHORS Baralle,F.E., Shoulders,C.C. and Proudfoot,N.J.
TITLE The primary structure of the human epsilon-globin gene
JOURNAL Cell 21, 621-626 (1980)
STANDARD full staff_review
REFERENCE 24 (bases 34440 to 36087; 39376 to 41004)
AUTHORS Slightom,J.L., Blechl,A.E. and Smithies,O.
TITLE Human fetal G Gamma- And A gamma-globin genes: complete nucleotide
sequences suggest that DNA can be exchanged between these
duplicated genes
JOURNAL Cell 21, 627-638 (1980)
STANDARD full staff_review
REFERENCE 25 (bases 54636 to 56620)
AUTHORS Spritz,R.A., DeRiel,J.K., Forget,B.G. and Weissman,S.M.
TITLE Complete nucleotide sequence of the human delta-globin gene
JOURNAL Cell 21, 639-646 (1980)
STANDARD full staff_review
REFERENCE 26 (bases 62052 to 64101)
AUTHORS Lawn,R.M., Efstratiadis,A., O'Connell,C. and Maniatis,T.
TITLE The nucleotide sequence of the human beta-globin gene
JOURNAL Cell 21, 647-651 (1980)
STANDARD full staff_review
REFERENCE 27 (sites)
AUTHORS Efstratiadis,A., Posakony,J.W., Maniatis,T., Lawn,R.M.,
O'Connell,C., Spritz,R.A., DeRiel,J.K., Forget,B.G., Weissman,S.M.,
Slightom,J.L., Blechl,A.E., Smithies,O., Baralle,F.E.,
Shoulders,C.C. and Proudfoot,N.J.
TITLE The structure and evolution of the human beta-globin gene family
JOURNAL Cell 21, 653-668 (1980)
STANDARD full staff_review
REFERENCE 28 (bases 17841 to 20001)
AUTHORS Baralle,F.E., Shoulders,C.C., Goodbourn,S., Jeffreys,A. and
Proudfoot,N.J.
TITLE The 5' flanking region of human epsilon-globin gene
JOURNAL Nucleic Acids Res. 8, 4393-4404 (1980)
STANDARD full staff_review
REFERENCE 29 (bases 62472 to 62631)
AUTHORS Orkin,S.H., Goff,S.C. and Nathan,D.G.
TITLE Heterogeneity of DNA deletion in gamma-delta-beta-thalassemia
JOURNAL J. Clin. Invest. 67, 878-884 (1981)
STANDARD full staff_review
REFERENCE 30 (sites)
AUTHORS Trecartin,R.F., Liebhaber,S.A., Chang,J.C., Lee,K.Y., Kan,Y.W.,
Furbetta,M., Angius,A. and Cao,A.
TITLE Beta-0 thalassemia in Sardinia is caused by a nonsense mutation
JOURNAL J. Clin. Invest. 68, 1012-1017 (1981)
STANDARD full staff_review
REFERENCE 31 (bases 32371 to 43746)
AUTHORS Shen,S.H., Slightom,J.L. and Smithies,O.
TITLE A history of the human fetal globin gene duplication
JOURNAL Cell 26, 191-203 (1981)
STANDARD full staff_review
REFERENCE 32 (sites)
AUTHORS Busslinger,M., Moschonas,N. and Flavell,R.A.
TITLE +beta thalassemia: Aberrant splicing results from a single point
mutation in an intron
JOURNAL Cell 27, 289-298 (1981)
STANDARD full staff_review
REFERENCE 33 (bases 32371 to 33236; 51996 to 52490)
AUTHORS Duncan,C.H., Jagadeeswaran,P., Wang,R.R. and Weissman,S.M.
TITLE Structural analysis of templates and RNA polymerase III transcripts
of Alu family sequences interspersed among the human beta-like
globin genes
JOURNAL Gene 13, 185-196 (1981)
STANDARD full staff_review
REFERENCE 34 (sites)
AUTHORS Orkin,S.H. and Goff,S.C.
TITLE Nonsense and frameshift mutations in beta-0-thalassemia detected in
cloned beta-globin genes
JOURNAL J. Biol. Chem. 256, 9782-9784 (1981)
STANDARD full staff_review
REFERENCE 35 (sites)
AUTHORS Westaway,D. and Williamson,R.
TITLE An intron nucleotide sequence variant in a cloned
beta-plus-thalassemia globin gene
JOURNAL Nucleic Acids Res. 9, 1777-1787 (1981)
STANDARD full staff_review
REFERENCE 36 (sites)
AUTHORS Moschonas,N., de Boer,E., Grosveld,F.G., Dahl,H.-H.M., Wright,S.,
Shewmaker,C.K. and Flavell,R.A.
TITLE Structure and expression of a cloned beta-0 thalassemic globin gene
JOURNAL Nucleic Acids Res. 9, 4391-4401 (1981)
STANDARD full staff_review
REFERENCE 37 (bases 60507 to 60966)
AUTHORS Spritz,R.A.
TITLE Duplication/deletion polymorphism 5'- to the human beta globin gene
JOURNAL Nucleic Acids Res. 9, 5037-5047 (1981)
STANDARD full staff_review
REFERENCE 38 (bases 59363 to 59611)
AUTHORS Miesfeld,R., Krystal,M. and Arnheim,N.
TITLE A member of a new repeated sequence family which is conserved
throughout eukaryotic evolution is found between the human delta
and beta globin genes
JOURNAL Nucleic Acids Res. 9, 5931-5947 (1981)
STANDARD full staff_review
REFERENCE 39 (bases 16595 to 17840)
AUTHORS Di Segni,G., Carrara,G., Tocchini-Valentini,G.R., Shoulders,C.C.
and Baralle,F.E.
TITLE Selective in vitro transcription of one of the two Alu family
repeats present in the 5' flanking region of the human
epsilon-globin gene
JOURNAL Nucleic Acids Res. 9, 6709-6722 (1981)
STANDARD full staff_review
REFERENCE 40 (sites)
AUTHORS Adams,J.G.III., Steinberg,M.H., Newman,M.V., Morrison,W.T.,
Benz,E.J.Jr. and Iyer,R.
TITLE Beta-thalassemia present in cis to a new beta-chain structural
variant, Hb Vicksburg [beta75(e19)leu->0]
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 78, 469-473 (1981)
STANDARD full staff_review
REFERENCE 41 (bases 61939 to 63842)
AUTHORS Spritz,R.A., Jagadeeswaran,P., Choudary,P.V., Biro,P.A.,
Elder,J.T., DeRiel,J.K., Manley,J.L., Gefter,M.L., Forget,B.G. and
Weissman,S.M.
TITLE Base substitution in an intervening sequence of a
beta-plus-thalassemic human globin gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 78, 2455-2459 (1981)
STANDARD full staff_review
REFERENCE 42 (sites)
AUTHORS Baird,M., Driscoll,C., Schreiner,H., Sciarratta,G.V., Sansone,G.,
Niazi,G., Ramirez,F. and Bank,A.
TITLE A nucleotide change at a splice junction in the human beta-globin
gene is associated with beta-0-thalassemia
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 78, 4218-4221 (1981)
STANDARD full staff_review
REFERENCE 43 (bases 62391 to 62439)
AUTHORS Flavell,R.A., Bud,H., Bullman,H., Busslinger,M., de Boer,E.,
de Kleine,A., Golden,L., Groffen,J., Grosveld,F.G., Mellor,A.L.,
Moschonas,N. and Weiss,E.
TITLE The structure and expression of mammalian gene clusters
JOURNAL Prog. Clin. Biol. Res. 103, 37-55 (1982)
STANDARD full staff_entry
REFERENCE 44 (sites)
AUTHORS Grosveld,F., Busslinger,M., Grosveld,G., Groffen,J., DeKleine,A.
and Flavell,R.A.
TITLE The structure and expression of the haemoglobin genes
JOURNAL Adv. Exp. Med. Biol. 158, 65-80 (1982)
STANDARD full staff_review
REFERENCE 45 (sites)
AUTHORS Treisman,R., Proudfoot,N.J., Shander,M. and Maniatis,T.
TITLE A single-base change at a splice site in a 0-beta-thalassemic gene
causes abnormal RNA splicing
JOURNAL Cell 29, 903-911 (1982)
STANDARD full staff_review
REFERENCE 46 (bases 63841 to 64101)
AUTHORS Poncz,M., Ballantine,M., Solowiejczyk,D., Barak,I., Schwartz,E. and
Surrey,S.
TITLE Beta-thalassemia in a Kurdish Jew: Single base changes in the
T-A-T-A box
JOURNAL J. Biol. Chem. 257, 5994-5996 (1982)
STANDARD full staff_entry
REFERENCE 47 (bases 61891 to 62216; 62393 to 62466)
AUTHORS Gorski,J., Fiori,M. and Mach,B.
TITLE A new nonsense mutation as the molecular basis for beta-0
thalassemia
JOURNAL J. Mol. Biol. 154, 537-540 (1982)
STANDARD full staff_review
REFERENCE 48 (bases 50734 to 51233)
AUTHORS Jagadeeswaran,P., Tuan,D., Forget,B.G. and Weissman,S.M.
TITLE A gene deletion ending at the midpoint of a repetitive DNA sequence
in one form of hereditary persistence of fetal haemoglobin
JOURNAL Nature 296, 469-470 (1982)
STANDARD full staff_review
REFERENCE 49 (sites)
AUTHORS Orkin,S.H., Kazazian,H.H.Jr., Antonarakis,S.E., Goff,S.C.,
Boehm,C.D., Sexton,J.P., Waber,P.G. and Giardina,P.J.
TITLE Linkage of beta-thalassemia mutations and beta-globin gene
polymorphisms with DNA polymorphisms in human beta-globin gene
cluster
JOURNAL Nature 296, 627-631 (1982)
STANDARD full staff_review
REFERENCE 50 (sites)
AUTHORS Ottolenghi,S. and Giglioni,B.
TITLE The deletion in a type of delta-0-beta-0-thalassemia begins in an
inverted AluI repeat
JOURNAL Nature 300, 770-771 (1982)
STANDARD full staff_review
REFERENCE 51 (bases 62669 to 62733)
AUTHORS Spence,S.E., Pergolizzi,R.G., Donovan-Peluso,M., Kosche,K.A.,
Dobkin,C.S. and Bank,A.
TITLE Five nucleotide changes in the large intervening sequence of a beta
globin gene in a beta-plus thalassemia patient
JOURNAL Nucleic Acids Res. 10, 1283-1294 (1982)
STANDARD full staff_review
REFERENCE 52 (bases 60694 to 62155)
AUTHORS Moschonas,N., de Boer,E. and Flavell,R.A.
TITLE The DNA sequence of the 5' flanking region of the human beta-globin
gene: Evolutionary conservation and polymorphic differences
JOURNAL Nucleic Acids Res. 10, 2109-2120 (1982)
STANDARD full staff_review
REFERENCE 53 (sites)
AUTHORS Allan,M., Grindlay,G.J., Stefani,L. and Paul,J.
TITLE Epsilon globin gene transcripts originating upstream of the mRNA
cap site in K562 cells and normal human embryos
JOURNAL Nucleic Acids Res. 10, 5133-5147 (1982)
STANDARD full staff_review
REFERENCE 54 (sites)
AUTHORS Kinniburgh,A.J., Maquat,L.E., Schedl,T., Rachmilewitz,E. and
Ross,J.
TITLE mRNA-deficient beta-0-thalassemia results from a single nucleotide
deletion
JOURNAL Nucleic Acids Res. 10, 5421-5427 (1982)
STANDARD full staff_review
REFERENCE 55 (bases 54456 to 54758)
AUTHORS Kimura,A., Matsunaga,E., Ohta,Y., Fujiyoshi,T., Matsuo,T.,
Nakamura,T., Imamura,T., Yanase,T. and Takagi,Y.
TITLE Structure of cloned delta-globin genes from a normal subject and a
patient with delta-thalassemia; sequence polymorphisms found in the
delta-globin gene region of Japanese individuals
JOURNAL Nucleic Acids Res. 10, 5725-5732 (1982)
STANDARD full staff_review
REFERENCE 56 (bases 10410 to 13774)
AUTHORS Shen,S.-H. and Smithies,O.
TITLE Human globin pseudo-beta-2 is not a globin-related sequence
JOURNAL Nucleic Acids Res. 10, 7809-7818 (1982)
STANDARD full staff_review
REFERENCE 57 (sites)
AUTHORS Spritz,R.A. and Orkin,S.H.
TITLE Duplication followed by deletion accounts for the structure of an
Indian deletion beta-0-thalassemia gene
JOURNAL Nucleic Acids Res. 10, 8025-8029 (1982)
STANDARD full staff_review
REFERENCE 58 (sites)
AUTHORS Ley,T.J. and Nienhuis,A.W.
TITLE A weak upstream promoter gives rise to long human beta-globin RNA
molecules
JOURNAL Biochem. Biophys. Res. Commun. 112, 1041-1048 (1983)
STANDARD full staff_review
REFERENCE 59 (sites)
AUTHORS Carlson,D.P. and Ross,J.
TITLE Human beta-globin promoter and coding sequences transcribed by RNA
polymerase III
JOURNAL Cell 34, 857-864 (1983)
STANDARD full staff_review
REFERENCE 60 (sites)
AUTHORS Allan,M., Lanyon,W.G. and Paul,J.
TITLE Multiple origins of transcription in the 4.5 kb upstream of the
epsilon-globin gene
JOURNAL Cell 35, 187-197 (1983)
STANDARD full staff_review
REFERENCE 61 (sites)
AUTHORS Vanin,E.F., Henthorn,P.S., Kioussis,D., Grosveld,F. and Smithies,O.
TITLE Unexpected relationships between four large deletions in the human
beta-globin gene cluster
JOURNAL Cell 35, 701-709 (1983)
STANDARD full staff_review
REFERENCE 62 (bases 50762 to 67222)
AUTHORS Poncz,M., Schwartz,E., Ballantine,M. and Surrey,S.
TITLE Nucleotide sequence analysis of the delta-beta-globin gene region
in humans
JOURNAL J. Biol. Chem. 258, 11599-11609 (1983)
STANDARD full staff_review
REFERENCE 63 (bases 62068 to 62068; 62297 to 62297; 62301 to 62301)
AUTHORS Treisman,R., Orkin,S.H. and Maniatis,T.
TITLE Specific transcription and RNA splicing defects in five cloned
beta-thalassaemia genes
JOURNAL Nature 302, 591-596 (1983)
STANDARD full staff_entry
REFERENCE 64 (bases 62208 to 62262)
AUTHORS Chang,J.C., Alberti,A. and Kan,Y.W.
TITLE A beta-thalassemia lesion abolishes the same MstII site as the
sickle mutation
JOURNAL Nucleic Acids Res. 11, 7789-7794 (1983)
STANDARD full staff_entry
REFERENCE 65 (bases 50734 to 53994)
AUTHORS Maeda,N., Bliska,J.B. and Smithies,O.
TITLE Recombination and balanced chromosome polymorphism suggested by DNA
sequences 5' to the human delta-globin gene
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80, 5012-5016 (1983)
STANDARD full staff_review
REFERENCE 66 (sites)
AUTHORS Kazazian,H.H.Jr., Orkin,S.H., Antonarakis,S.E., Sexton,J.P.,
Boehm,C.D. and Waber,P.G.
TITLE Molecular characterization of seven beta-thalassemia mutations in
Asian Indians
JOURNAL EMBO J. 3, 593-596 (1984)
STANDARD full staff_review
REFERENCE 67 (sites)
AUTHORS Guida,S., Giglioni,B., Ottolenghi,S., Camaschella,C. and Saglio,G.
TITLE The beta-globin gene in Sardinian delta-beta-0-thalassemia carries
a C -> T nonsense mutation at codon 39
JOURNAL EMBO J. 3, 785-787 (1984)
STANDARD full staff_review
REFERENCE 68 (sites)
AUTHORS Giglioni,B., Casini,C., Mantovani,R., Merli,S., Comi,P.,
Ottolenghi,S., Saglio,G., Camaschella,C. and Mazza,U.
TITLE A molecular study of a family with Greek hereditary persistence of
fetal hemoglobin and beta-thalassemia
JOURNAL EMBO J. 3, 2641-2645 (1984)
STANDARD full staff_review
REFERENCE 69 (sites)
AUTHORS Kimura,A., Ohta,Y., Fukumaki,Y. and Takagi,Y.
TITLE A fusion gene in man: DNA sequence analysis of the abnormal globin
gene of hemoglobin Miyada
JOURNAL Biochem. Biophys. Res. Commun. 119, 968-974 (1984)
STANDARD full staff_review
REFERENCE 70 (bases 61575 to 61641)
AUTHORS Semenza,G.L., Malladi,P., Surrey,S., Delgrosso,K., Poncz,M. and
Schwartz,E.
TITLE Detection of a novel DNA polymorphism in the beta-globin gene
cluster
JOURNAL J. Biol. Chem. 259, 6045-6048 (1984)
STANDARD full staff_entry
REFERENCE 71 (sites)
AUTHORS Orkin,S.H., Antonarakis,S.E. and Kazazian,H.H.Jr.
TITLE Base substitution at position -88 in a beta-thalassemic globin gene
JOURNAL J. Biol. Chem. 259, 8679-8681 (1984)
STANDARD full staff_review
REFERENCE 72 (bases 45354 to 47481)
AUTHORS Chang,L.Y. and Slightom,J.L.
TITLE Isolation and nucleotide sequence analysis of the beta-type globin
pseudogene from human, gorilla and chimpanzee
JOURNAL J. Mol. Biol. 180, 767-784 (1984)
STANDARD full staff_review
REFERENCE 73 (sites)
AUTHORS Grindlay,G.J., Lanyon,W.G., Allan,M. and Paul,J.
TITLE Alternative sites of transcription initiation upstream of the
canonical cap site in human gamma-globin and beta-globin genes
JOURNAL Nucleic Acids Res. 12, 1811-1821 (1984)
STANDARD full staff_review
REFERENCE 74 (sites)
AUTHORS Stoeckert,C.J., Collins,F.S. and Weissman,S.M.
TITLE Human fetal globin DNA sequences suggest novel conversion event
JOURNAL Nucleic Acids Res. 12, 4469-4479 (1984)
STANDARD full staff_review
REFERENCE 75 (sites)
AUTHORS Mager,D.L. and Henthorn,P.S.
TITLE Identification of a retrovirus-like repetitive element in human DNA
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 81, 7510-7514 (1984)
STANDARD full staff_review
REFERENCE 76 (bases 19120 to 61794; 19120 to 61794)
AUTHORS Collins,F.S. and Weissman,S.M.
TITLE The molecular genetics of human hemoglobin
JOURNAL Prog. Nucleic Acid Res. Mol. Biol. 31, 315-462 (1984)
STANDARD full staff_review
REFERENCE 77 (bases 34294 to 34294; 34300 to 34300; 34339 to 34339)
AUTHORS Gilman,J.G. and Huisman,T.H.
TITLE DNA sequence variation associated with elevated fetal gamma-G
globin production
JOURNAL Blood 66, 783-787 (1985)
STANDARD simple staff_entry
REFERENCE 78 (sites)
AUTHORS Ruskin,B., Greene,J.M. and Green,M.R.
TITLE Cryptic branch point activation allows accurate in vitro splicing
of human beta-globin intron mutants
JOURNAL Cell 41, 833-844 (1985)
STANDARD full staff_review
REFERENCE 79 (sites)
AUTHORS Lang,K.M. and Spritz,R.A.
TITLE Cloning specific complete polyadenylated 3'-terminal cDNA segments
JOURNAL Gene 33, 191-196 (1985)
STANDARD full staff_review
REFERENCE 80 (bases 1 to 19312)
AUTHORS Li,Q., Powers,P.A. and Smithies,O.
TITLE Nucleotide sequence of 16 kilobase pairs of DNA 5' to the human
epsilon-globin gene
JOURNAL J. Biol. Chem. 260, 14901-14910 (1985)
STANDARD full staff_review
REFERENCE 81 (sites)
AUTHORS Gelinas,R., Endlich,B., Pfeiffer,C., Yagi,M. and
Stamatoyannopoulos,G.
TITLE G to A substitution in the distal CCAAT box of the
alpha-gamma-globin gene in Greek hereditary persistence of fetal
haemoglobin
JOURNAL Nature 313, 323-325 (1985)
STANDARD full staff_review
REFERENCE 82 (sites)
AUTHORS Collins,F.S., Metherall,J.E., Yamakawa,M., Pan,J., Weissman,S.M.
and Forget,B.G.
TITLE A point mutation in the alpha-gamma-globin gene promoter in Greek
hereditary persistence of fetal haemoglobin
JOURNAL Nature 313, 325-326 (1985)
STANDARD full staff_review
REFERENCE 83 (bases 67089 to 73326)
AUTHORS Hattori,M., Hidaka,S. and Sakaki,Y.
TITLE Sequence analysis of a KpnI family member near the 3'end of human
beta-globin gene
JOURNAL Nucleic Acids Res. 13, 7813-7827 (1985)
STANDARD full staff_review
REFERENCE 84 (sites)
AUTHORS van Santen,V.L. and Spritz,R.A.
TITLE mRNA precursor splicing in vivo: Sequence requirements determined
by deletion analysis of an intervening sequence
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 2885-2889 (1985)
STANDARD full staff_review
REFERENCE 85 (sites)
AUTHORS Tuan,D., Solomon,W., Li,Q. and London,I.M.
TITLE The 'beta-like-globin' gene domain in human erythroid cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 6384-6388 (1985)
STANDARD full staff_review
REFERENCE 86 (sites)
AUTHORS Chabot,B., Black,D.L., LeMaster,D.M. and Steitz,J.A.
TITLE The 3' splice site of pre-messenger RNA is recognized by a small
nuclear ribonucleoprotein
JOURNAL Science 230, 1344-1349 (1985)
STANDARD full staff_review
REFERENCE 87 (bases 21372 to 21378)
AUTHORS Collins,F.S.
JOURNAL Unpublished (1986)
STANDARD full staff_review
REFERENCE 88 (bases 58817 to 58976; 63054 to 63313)
AUTHORS Popovich,B.W., Rosenblatt,D.S., Kendall,A.G. and Nishioka,Y.
TITLE Molecular characterization of an atypical beta-thalassemia caused
by a large deletion in the 5' beta-globin gene region
JOURNAL Am. J. Hum. Genet. 39, 797-810 (1986)
STANDARD full staff_entry
REFERENCE 89 (bases 62391 to 62437)
AUTHORS Metherall,J.E., Collins,F.S., Pan,J., Weissman,S.M. and Forget,B.G.
TITLE Beta-0 thalassemia caused by a base substitution that creates an
alternative splice acceptor site in an intron
JOURNAL EMBO J. 5, 2551-2557 (1986)
STANDARD full staff_entry
REFERENCE 90 (bases 54892 to 54910)
AUTHORS Lapoumeroulie,C., Pagnier,J., Bank,A., Labie,D. and
Krishnmoorthy,R.
TITLE Beta thalassemia due to a novel mutation in IVS 1 sequence donor
site consensus sequence creating a restriction site
JOURNAL Biochem. Biophys. Res. Commun. 139, 709-713 (1986)
STANDARD full staff_entry
REFERENCE 91 (bases 37658 to 37695; 40180 to 40217)
AUTHORS Tate,V.E., Hill,A.V., Bowden,D.K., Sadler,J.R., Weatherall,D.J. and
Clegg,J.B.
TITLE A silent deletion in the beta-globin gene cluster
JOURNAL Nucleic Acids Res. 14, 4743-4750 (1986)
STANDARD full staff_entry
REFERENCE 92 (sites)
AUTHORS Prchal,J.T., Cashman,D.P. and Kan,Y.W.
TITLE Hemoglobin Long Island is caused by a single mutation (adenine to
cytosine) resulting in a failure to cleave amino-terminal
methionine
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83, 24-27 (1986)
STANDARD full staff_review
REFERENCE 93 (bases 59607 to 59736; 72229 to 72358)
AUTHORS Gilman,J.G. and Abraham,J.
TITLE DNA sequence analysis of the Dutch beta-0-thalassemia deletion
JOURNAL Biomed. Biochim. Acta 46, 131-135 (1987)
STANDARD full staff_entry
REFERENCE 94 (bases 43741 to 50739)
AUTHORS Miyamoto,M.M., Slightom,J.L. and Goodman,M.
TITLE Phylogenetic relations of humans and African apes from DNA
sequences in the pseudo-eta-globin region
JOURNAL Science 238, 369-373 (1987)
STANDARD full staff_entry
REFERENCE 95 (bases 55056 to 55070)
AUTHORS Atweh,G.F., Brickner,H.E., Zhu,X.-X., Kazazian,H.H.Jr. and
Forget,B.G.
TITLE New amber mutation in a beta-thalassemic gene with nonmeasurable
levels of mutant messenger RNA in vivo
JOURNAL J. Clin. Invest. 82, 557-561 (1988)
STANDARD full staff_entry
REFERENCE 96 (sites)
AUTHORS Fei,Y.J., Stoming,T.A., Efremov,G.D., Efremov,D.G., Battacharia,R.,
Gonzalez-Redondo,J.M., Altay,C., Gurgey,A. and Huisman,T.H.
TITLE Beta-thalassemia due to a T->A mutation within the ATA box
JOURNAL Biochem. Biophys. Res. Commun. 153, 741-747 (1988)
STANDARD full staff_review
REFERENCE 97 (sites)
AUTHORS Engelke,D.R., Hoener,P.A. and Collins,F.S.
TITLE Direct sequencing of enzymatically amplified human genomic DNA
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85, 544-548 (1988)
STANDARD full staff_review
COMMENT
[1] cRNA fragments.
[2] mRNA.
[5] sites; polyadenylation signal and site for the beta gene.
[4] cDNA from normal and thalassemic mRNAs.
[6] cDNA.
[9] mRNA and cDNA fragments.
[10] mRNA.
[7] cDNA.
[13] see comment below for 35872 to 35964 - may be 40788 to 40880.
[19] sites; amber mutation at codon 17 of the beta chain.
[22] sites; gene order for the beta-like globin cluster.
[27] sites; consensus sequences in the promoter regions.
[40] sites; mutation associated with Hb Vicksburg.
[41] beta thalassemia DNA.
[42] sites; mutation associated with beta-0 thalassemia.
[35] sites; mutation associated with beta-plus thalassemia.
[36] sites; mutation associated with beta-0 thalassemia.
[37] six alleles over this span.
[34] sites; mutations associated with beta-0 thalassemia.
[30] sites; mutation associated with beta-0 thalassemia.
[53] sites; alternative cap sites for mRNA.
[54] sites; mutation associated with beta-plus thalassemia.
[57] sites; deletion mutation associated with beta-0 thalassemia;.
[49] sites; mutations associated with beta thalassemias.
[50] sites; deletion mutation; for sequence, see separate entry.
[62] DNA from Kurdish Jew with thalassemia.
[58] sites; promoter region for beta gene.
[59] sites; termini for RNA polymerase III transcripts.
[60] sites; alternative cap sites for mRNA.
[61] sites; deletion mutations associated with thalassemias;.
[65] for the R allele;.
[73] sites; beta and gamma gene cap sites.
[71] sites; mutation associated with beta thalassemia.
[69] sites; Miyada Hb lesion; for sequence, see separate entry.
[75] sites; hsRTVL-H element; for sequence, see separate entry.
[66] sites; mutations associated with thalassemia.
[67] sites; mutation associated with thalassemia.
[68] sites; mutation associated with thalassemia.
[76] see comment; review.
[74] sites; mutations in the A-gamma gene.
[81] sites; mutation in promoter region leading to HPFH;.
[82] sites; mutation in promoter region leading to HPFH.
[85] sites; DNAse I hypersensitivity sites in the region.
[78] sites; cryptic branch points in beta IVS1.
[79] sites; 3' segments of beta and G-gamma cDNAs.
[84] sites; mutational analysis of G-gamma IVS-2.
[86] sites; small nuclear ribonucleoprotein binding site to mRNA.
[92] sites; hemoglobin Long Island mutation.
[94] revises [72].
[96] sites; mutations resulting in beta-thalassemia.
[97] sites; sickle cell anemia mutation site.
[32] sites; thalassemia mutations.
[44] sites; thalassemia mutations.
[45] sites; thalassemia mutation.
[21] sites; thalassemia mutation.
[89] beta-0 thalassemia mutations.
This 73 kb sequence, which includes all of the known beta genes in
the cluster on chromosome 11, was compiled from the following
sources primarily:
bases references
------ ------------
1 to 10409 [80]
10410 to 13774 [56]
13775 to 16594 [80]
16595 to 21399 [23], [28], [39]
21400 to 32370 [63; see acknowledgments therein; bases
31906-32038 sequenced on one strand only]
32371 to 43746 [31]
43747 to 50733 [94]
50734 to 67222 [48], [62]
67223 to 73326 [83]
Other sequence work is referenced and annotated below. Oliver
Smithies provided the sequence in [80] via Arpanet and Francis
Collins supplied a diskette with the sequence in [76].
Computer-readable sequence for [94] kindly provided by
M.M.Miyamoto, 15-FEB-1988.
The five beta-like globin genes are found within a 45 kb cluster on
chromosome 11 in the following order:
5'-epsilon -G-gamma -A-gamma -delta -beta-3' [22]
Additionally, the pseudogene beta-1 is located between the A-gamma
and delta genes [72]. A region 5' to the epsilon gene was thought
to be another pseudogene; however [56] shows this not to be so.
These embryonic, fetal and adult beta-like genes have the same
overall exonic structure, leading to the conclusion that they are
derived from one ancestral gene. In particular, they have many
consensus sequences and repetitive sequences in common which have
been analyzed by [27] and [76].
Epsilon gene
------------
The epsilon globin gene (hbe below) is normally expressed in the
embryonic yolk sac: two epsilon chains together with two zeta
chains (an alpha-like globin; see separate entry) constitute the
embryonic hemoglobin Hb Gower I; two epsilon chains together with
two alpha chains form the embryonic Hb Gower II. Both of these
embryonic hemoglobins are normally supplanted by fetal, and later,
adult hemoglobin.
The promoter region sequences 'ccaat', 'ata' and 'cttccg' found at
19421, 19476 and 19513 are characteristic of all human beta-like
genes, as well as of some other mammalian genes, and are thought to
influence initiation of transcription and translation [27],[76].
However, at least nine alternative cap sites which do not possess
these conserved sequences have been found upstream from the
so-called canonical cap sites at 19504 and 19506 [53],[60].
The Alu family sequences found at 16910-17176 and 17945-18208 are
typical of the 5' flanking regions of the beta-like globin genes
[23],[39]. The first of these bipolar repeats has been shown to be
active as a template for RNA polymerase III [39].
G-gamma and A-gamma genes
-------------------------
The gamma globin genes (hbgg and hbga below) are normally expressed
in the fetal liver, spleen and bone marrow. Two gamma chains
together with two alpha chains constitute fetal hemoglobin (HbF)
which is normally replaced by adult hemoglobin (HbA) at birth. In
some beta-thalassemias and related conditions (HPFH or 'hereditary
persistence of fetal hemoglobin'), gamma chain production continues
into adulthood. The mapping of deletions in these pathologies is
therefore of special interest with regard to developmental control
mechanisms.
The two types of gamma chains differ at residue 136 where glycine
is found in the G-gamma product and alanine is found in the A-gamma
product. The former is predominant at birth. Because of the
sequence identity of the two genes over large stretches, it was not
always possible in the early work to know which sequence was being
investigated [13],[15],[17]. Moreover, because allelic variation
has been reported for each of these non-allelic genes, further
sequence work is required to determine the consensus sequence for
each. Thus far the sequences of two A-gamma alleles have been
reported ([24]; see separate entry which annotates the allelic
variation). The second introns for the hbgg and hbga genes shown
below contain 886 and 866 bases respectively, while their alleles
on the opposing chromosome have 904 and 876 bases for the
corresponding introns. [24] and [31] present an analysis of this
phenomenon and conclude that intergenic exchange can occur in human
germ line cells with significant frequency.
Given the above-mentioned uncertainties with regard to polymorphism
and material, differences, where annotated, are treated as
variations rather than as conflicts.
The promoter region sequences 'ccaat', 'ata' and 'cttctg' found at
bases 34408, 34466 and 34503 in the hbgg gene, and bases 39344,
39402 and 39439 in the hbga gene, are characteristic of all
beta-like genes, as well as of some other mammalian genes, and are
thought to influence transcription and translation [27],[76]. The
gamma genes each manifest duplicate 'ccaat' boxes at positions
34381 (hbgg) and 39317 (hbga). Alternative cap sites are active in
vitro upstream from the canonical cap sites at 34496 and 39432: at
bases 34416, 34426, 34436 and 34446 for hbgg, and at bases 39352,
39362, 39372 and 39382 for hbga [73]. Alternative cap sites have
also been reported for epsilon and beta mRNAs when there is no
duplication of the 'ccaat' sequence. [81] and [82] show that the
distal 'ccaat' box for the hbga gene (for the B allele -- see
separate sequence) has some vital function: a g -> a mutation at
base 39315 is apparently responsible for one form of Greek HPFH.
The Alu family sequences found at bases 32408-32741 (approx.) and
37343-37580 (approx.) are typical of the beta-like globin Alu's
[27],[76],[33],[31]. A study of the hbgg repeat has revealed RNA
transcription by polymerase III [33]( also reported for Alu regions
in the 5' flanks of the epsilon and beta genes).
Pseudo-beta-1
-------------
Human, gorilla and chimpanzee beta-like pseudogenes were sequenced
and compared (see separate entries for the other primate sequences)
by [72] and revised by [94]. The pseudogene structure was deduced
through comparison with the A-gamma globin gene. Base substitutions
in the initiation codon and in codons downstream, that create
internal termination signals in exons 2 and 3, make this sequence a
pseudogene.
Delta and beta genes
--------------------
The delta and beta genes (denoted hbd and hbb below) are normally
expressed in the adult: two alpha chains plus two beta chains
constitute HbA, which in normal adult life comprises about 97% of
the total hemoglobin. Two alpha chains plus two delta chains
constitute HbA-2, which with HbF comprises the remaining 3% of
adult hemoglobin.
The sequence given below has been reconstructed from the sequences
reported by [48] and [62]: the mutation at base 62161 is apparently
sufficient to distinguish the Kurdish Jew thalassemic sequence from
a normal (consensus) beta globin DNA; [62] has resolved all
sequence differences to date with exception of the differences
reported herein as variations.
The promoter region sequences 'ccaat', 'ata' and 'cttctg' found at
bases 54690, 54727 and 54765 in the delta gene, and at bases 62079,
62124 and 62162 in the beta gene, are characteristic of all
beta-like genes, as well as of some other mammalian genes, and are
thought to influence transcription and translation [27],[76].
However, alternative cap sites have been found for these genes as
well as other beta-like genes [58],[73].
[96] describes the mutation (substitution of 'a' for 't' at
position 62125, thereby destroying the promoter) found in an Hb
Lepore-beta+ -thalassemia patient, who was homozygous for this
mutation. The father who had the simple beta-thalassemia trait was
found to be heterozygous.
A form of thalassemia exists, where 19 bp are added after the first
exon, starting at position 62408 and ending at a stop codon at
position 62424-62426 [32],[44],[43]. This aberrant splicing is
caused by a mutation of 'g' to 'a' in the first intron of
beta-hemoglobin at position 62406. The substitution of a 'g' for a
't' at position 62412 also causes premature splicing and results in
an abnormal and abbreviated beta hemoglobin [89].
Another form of beta-thalassemia is produced by the substitution of
an 'a' for a 'g' at position 62650. This causes a readthrough at
the exon/intron boundary of exon 2/intron 2 [45].
The Alu family sequences found at bases 50933, 51994, 65531 and
66794 are again typical of the beta-like globin Alu's. These
sequences are of considerable interest in relation to regulation,
recombination and transcription by RNA polymerase III.
There are non-Alu repetitive elements in the gene cluster that have
been partially characterized: the EC-1 repeat [38] and a
retrovirus-like element in the 3' flank about 300 kb downstream of
this sequence [75] (see separate entry); there are numerous repeats
in the 5' flank which will be included in a future update [80].
Reference [83] has characterized a novel KpnI family sequence in
the 3' flank of the cluster.
Potential polyadenylation signals were identified for the following
genes:
hbe positions 21073-21078
hbgg positions 36061-36066
hbga positions 40977-40982
hbd positions 56383-56388
hbb positions 63736-63741
FEATURES Location/Qualifiers
exon <19559..19650
/note="epsilon-globin, exon 1"
/gene="HBE1"
exon <34549..34640
/note="G-gamma globin, exon 1"
/gene="HBG2"
exon <39485..39576
/note="A-gamma globin, exon 1"
/gene="HBG1"
exon <54808..54899
/note="delta-globin, exon 1"
/gene="HBD"
exon <62205..62296
/note="beta-globin, exon 1"
/gene="HBB"
exon <62205..62296
/note="beta-globin thalassemia, exon 1 [32],[44]"
exon <45728..45818
/note="pseudo-hbp, exon 1 [72]"
CDS join(19559..19650,19773..19995,20851..20979)
/note="epsilon-globin"
/codon_start=1
/translation="MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFD
SFGNLSSPSAILGNPKVKAHGKKVLTSFGDAIKNMDNLKPAFAKLSELHCDKLHVDPE
NFKLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAIALAHKYH"
CDS join(34549..34640,34763..34985,35872..36000)
/note="G-gamma globin"
/codon_start=1
/translation="MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFD
SFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPE
NFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTGVASALSSRYH"
CDS join(39485..39576,39699..39921,40788..40916)
/note="A-gamma globin"
/codon_start=1
/translation="MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFD
SFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPE
NFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVASALSSRYH"
CDS join(54808..54899,55028..55250,56149..56277)
/note="delta-globin"
/codon_start=1
/translation="MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFE
SFGDLSSPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDPE
NFRLLGNVLVCVLARNFGKEFTPQMQAAYQKVVAGVANALAHKYH"
CDS join(62205..62296,62427..62649,63500..63628)
/note="beta-globin"
/codon_start=1
/translation="MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFE
SFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPE
NFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH"
CDS join(62205..62296,62408..62426)
/note="beta-globin thalassemia"
/codon_start=1
/translation="MVHLTPEEKSAVTALWGKVNVDEVGGEALGSLFSHP"
CDS join(45728..45818,45940..46163,47015..47142)
/pseudo
/note="pseudo-hbp"
/codon_start=1
repeat_region 10597..10611
/note="Alu flank repeat 5' copy"
repeat_region 10612..10924
/note="Alu family repeat"
repeat_region 10925..10939
/note="Alu flank repeat 3' copy"
repeat_region complement(16910..17176)
/note="Alu family repeat [28],[39]"
variation 17864..17866
/note="cag in clone lambda-epsilon; g in ph 1.8 [28]"
repeat_region 17945..18208
/note="Alu family repeat [28],[39]"
prim_transcript 19289..21098
/note="hbe mRNA (alt.) [23],[53],[60]"
prim_transcript 19504..21098
/note="hbe mRNA (alt.) [23],[53],[60]"
prim_transcript 19506..21098
/note="hbe mRNA (alt.) [23],[53],[60]"
intron 19651..19772
/note="hbe intron 1 [23]"
exon 19773..19995
/note="epsilon-globin, exon 2"
intron 19996..20850
/note="hbe intron 2 [23]"
exon 20851..>20979
/note="epsilon-globin, exon 3"
variation 21001
/note="g in [76]; c in [23]"
old_sequence 21372..21378
unsure 31906..32038
/note="sequenced on one strand only [76]"
repeat_region 32408..32424
/note="Alu flank repeat 5' copy [33]"
repeat_region 32425..32729
/note="Alu family repeat [33]"
variation 32626
/note="g in [31]; a in [33]"
repeat_region 32730..32746
/note="Alu flank repeat 3' copy [33]"
variation 32761..32762
/note="ag in [31]; ga in [33]"
variation 33204
/note="a in [31]; g in [33]"
variation 33216
/note="a in [31]; g in [33]"
mutation 34294
/note="c in wt; g in persons with elevated gamma chain
[77]"
mutation 34300
/note="c in wt; t in persons with elevated gamma chain
[77]"
mutation 34339
/note="c in wt; t in high G-gamma SS; beta thalassemia;
and in low Hb F G-gamma-beta+-HPHF and HPFH [77]"
mutation 34379
/note="g in wt; a in persons with elevated gamma chain
[77]"
prim_transcript 34496..36087
/note="hbgg mRNA [15],[24],[27]"
intron 34641..34762
/note="hbgg intron 1 [24]"
exon 34763..34985
/note="G-gamma globin, exon 2"
intron 34986..35871
/note="hbgg intron 2 [24]"
exon 35872..>36000
/note="G-gamma globin, exon 3"
mutation 37675..40197
/note="g-25 kb-c in wt; gc in silent deletion [91]"
mutation 39315
/note="g in wt (b allele, see separate sequence); a in
HPFH [81],[82]"
prim_transcript 39432..41003
/note="hbga mRNA [5],[15],[24],[27]"
variation 39456
/note="a in [31]; g in [15]"
intron 39577..39698
/note="hbga intron 1 [24]"
exon 39699..39921
/note="A-gamma globin, exon 2"
intron 39922..40787
/note="hbga intron 2 [17],[24]"
exon 40788..>40916
/note="A-gamma globin, exon 3"
variation 43800..43802
/note="gat in [94]; gt in [76]"
variation 43848..43850
/note="ttg in [94]; tg in [76]"
variation 43861
/note="t in [94]; c in [76]"
variation 44140
/note="t in [94]; c in [76]"
variation 45087..45095
/note="aaaaaaaaa in [94]; aa in [76]"
variation 45245..45246
/note="ca in [94]; ctca in [76]"
variation 45298
/note="t in [94]; c in [76]"
variation 45315
/note="c in [94]; t in [76]"
variation 45317
/note="t in [94]; c in [76]"
variation 45327..45329
/note="cat in [94]; ct in [76]"
variation 45335..45337
/note="tta in [94]; ta in [76]"
variation 45339..45341
/note="tag in [94]; tg in [76]"
mRNA 45675..47388
/pseudo
/note="pseudo-hbp mRNA [72]"
intron 45819..45941
/note="pseudo-hbp intron 1 (no splice consensus at 45941
[17],[24],[72]"
exon 45940..46163
/pseudo
/note="pseudo-hbp, exon 2 [72]"
intron 46164..47014
/note="pseudo-hbp intron 2 (no splice consensus at 46164
[72]"
exon 47015..>47142
/note="pseudo-hbp, exon 3 [72]"
repeat_region complement(50907..50912)
/note="Alu flank repeat 3' copy [48],[62]"
repeat_region complement(50933..51216)
/note="Alu family repeat [48],[62]"
repeat_region complement(51217..51222)
/note="Alu flank repeat 5' copy [48],[62]"
repeat_region 51984..51993
/note="Alu flank repeat 5' copy [62]"
repeat_region 51994..52277
/note="Alu family repeat [33],[62]"
repeat_region 52304..52313
/note="Alu flank repeat 3' copy [62]"
prim_transcript 54758..56407
/note="hbd mRNA [25]"
intron 54900..55027
/note="hbd intron 1 [25]"
mutation 54904
/note="g in wt; a in beta thalassemia [90]"
exon 55028..55250
/note="delta-globin, exon 2"
mutation 55065
/note="g in wt; t in beta-thalassemia Glu->stop"
intron 55251..56148
/note="hbd intron 2 [25]"
variation 55541
/note="ct in [55],[62],[76]; tc in [25]"
variation 55589..55590
/note="ct in [62],[76]; c in [25]; cc in [55]"
exon 56149..>56277
/note="delta-globin, exon 3"
mutation 58873..63111
/note="a-4239 bp-c in wt; ac in atypical beta-thalassemia
[88]"
mutation 59681..72304
/note="t-12622 bp-t in wt; tt in Dutch beta-0- thalassemia
[93]"
variation 60763..60768
/note="tatttt in [62],[76]; t in [37]"
variation 60850
/note="a in [37],[62],[76]; g in [52]"
variation 60860
/note="c in [62],[76]; ca in [37],[52]"
variation 61166
/note="c in [52],[62],[76]; g in [52]"
variation 61312
/note="c in [62],[76]; t in [52]"
variation 61326
/note="t in [62],[76]; tt in [52]"
allele 61604
/note="t in wt; c in Albanian allele (produces RsaI site)
[70]"
allele 61626..61627
/note="tt in wt; tatat in Albanian allele [70]"
variation 61681
/note="a in [62],[76]; g in [52]"
variation 61771
/note="gc in [62],[76]; g in [52]"
variation 61791
/note="g in [62]; a in [76]"
variation 61815
/note="t in [55],[62],[76]; c in [52]"
variation 61842
/note="g in [62],[76]; c in [52]"
variation 61940
/note="g in [52],[62],[76]; c in [41]"
variation 61950
/note="a in [52],[62],[76]; t in [41]"
mutation 62068
/note="c in wt; g in beta-thalassemia [63]"
mutation 62125
/note="t in normal promoter; a in thalassemia patient (Hb
Lepore-beta+ -thal)"
mutation 62127
/note="a in [26],[41],[52]; c in [62],[76],[J. Biol. C"
prim_transcript 62155..63760
/note="hbb mRNA [5],[11],[10],[7],[26]"
variation 62174
/note="c in [62],[76]; t in [49]"
variation 62213
/note="c in [26],[62],[76]; t in [49]"
mutation 62223..62225
/note="gag in wt; gg in beta-thalassemia [64]"
mutation 62224
/note="a in normal hbb; t in sickle cell anemia 78]"
mutation 62256
/note="a in wt; t in thalassemia [21]"
intron 62297..62426
/note="hbb intron 1 [10],[26],[55]"
mutation 62297
/note="g in wt; a in thalassemia [63]"
intron 62297..62407
/gene="HBB thalassemia"
mutation 62301
/note="g in wt; c in thalassemia [63]"
mutation 62302
/note="t in wt; c in thalassemia [63]"
mutation 62406
/note="g in wt; a in thalassemia [32],[44],[43],[89]"
exon 62408..>62426
/note="beta-globin thalassemia, exon 2 [32],[44]"
mutation 62412
/note="t in wt; g in thalassemia [89]"
exon 62427..62649
/note="beta-globin, exon 2"
mutation 62448
/note="g in wt; a in a form of thalassemia [32]"
intron 62650..63499
/note="hbb intron 2 [10],[12],[26]"
mutation 62650
/note="g in wt; a in a form of thalassemia [45]"
variation 62665
/note="c in [26],[49],[62],[76]; g in [49]"
variation 62723
/note="g in [26],[62],[76]; t in [49]"
variation 62730
/note="c in [26],[62],[76]; t in [49]"
variation 63315
/note="t in [26],[49],[62],[76]; c in [49]"
mutation 63394
/note="c in wt; g thalassemia [63] (causes an extra exon)"
exon 63500..>63628
/note="beta-globin, exon 3"
variation 63848..63849
/note="ta in [62],[76]; t in [26]"
mutation 63936..63937
/note="ct in wt; cct in a form of thalassemia [46]"
variation 63936
/note="c in [62],[76]; cc in [26]"
mutation 63975..63976
/note="tt in wt; aa in a form of thalassemia [46]"
variation 63975..63976
/note="aa in [37],[62],[76]; tt in [26]"
variation 63992
/note="g in [37],[62],[76]; c in [26]"
repeat_region 65508..65520
/note="Alu flank repeat 5' copy [62],[76]"
repeat_region 65531..65785
/note="Alu family repeat [62],[76]"
repeat_region 65786..65798
/note="Alu flank repeat 3' copy [62],[76]"
repeat_region 66783..66793
/note="Alu flank repeat 5' copy [62],[76]"
repeat_region 66794..67060
/note="Alu family repeat [62],[76]"
repeat_region 67087..67097
/note="Alu flank repeat 3' copy [62],[76]"
repeat_region 67089..73213
/note="KpnI family repeat [83]"
BASE COUNT 22072 a 14169 c 14789 g 22293 t 3 others
ORIGIN 1 bp upstream of EcoRI site; chromosome 11p15 [J. Biol. Chem. 260,
1 gaattctaat ctccctctca accctacagt cacccatttg gtatattaaa gatgtgttgt
61 ctactgtcta gtatccctca agtagtgtca ggaattagtc atttaaatag tctgcaagcc
121 aggagtggtg gctcatgtct gtaattccag cactggagag gtagaagtgg gaggactgct
181 tgagctcaag agtttgatat tatcctggac aacatagcaa gacctcgtct ctacttaaaa
241 aaaaaaaaat tagccaggca tgtgatgtac acctgtagtc ccagctactc aggaggccga
301 aatgggagga tcccttgagc tcaggaggtc aaggctgcag tgagacatga tcttgccact
361 gcactccagc ctggacagca gagtgaaacc ttgcctcacg aaacagaata caaaaacaaa
421 caaacaaaaa actgctccgc aatgcgcttc cttgatgctc taccacatag gtctgggtac
481 tttgtacaca ttatctcatt gctgttcgta attgttagat taattttgta atattgatat
541 tattcctaga aagctgaggc ctcaagatga taacttttat tttctggact tgtaatagct
601 ttctcttgta ttcaccatgt tgtaactttc ttagagtagt aacaatataa agttattgtg
661 agtttttgca aacacagcaa acacaacgac ccatatagac attgatgtga aattgtctat
721 tgtcaattta tgggaaaaca agtatgtact ttttctacta agccattgaa acaggaataa
781 cagaacaaga ttgaaagaat acattttccg aaattacttg agtattatac aaagacaagc
841 acgtggacct gggaggaggg ttattgtcca tgactggtgt gtggagacaa atgcaggttt
901 ataatagatg ggatggcatc tagcgcaatg actttgccat cacttttaga gagctcttgg
961 ggaccccagt acacaagagg ggacgcaggg tatatgtaga catctcattc tttttcttag
1021 tgtgagaata agaatagcca tgacctgagt ttatagacaa tgagcccttt tctctctccc
1081 actcagcagc tatgagatgg cttgccctgc ctctctacta ggctgactca ctccaaggcc
1141 cagcaatggg cagggctctg tcagggcttt gatagcacta tctgcagagc cagggccgag
1201 aaggggtgga ctccagagac tctccctccc attcccgagc agggtttgct tatttatgca
1261 tttaaatgat atatttattt taaaagaaat aacaggagac tgcccagccc tggctgtgac
1321 atggaaacta tgtagaatat tttgggttcc attttttttt ccttctttca gttagaggaa
1381 aaggggctca ctgcacatac actagacaga aagtcaggag ctttgaatcc aagcctgatc
1441 atttccatgt catactgaga aagtccccac ccttctctga gcctcagttt ctctttttat
1501 aagtaggagt ctggagtaaa tgatttccaa tggctctcat ttcaatacaa aatttccgtt
1561 tattaaatgc atgagcttct gttactccaa gactgagaag gaaattgaac ctgagactca
1621 ttgactggca agatgtcccc agaggctctc attcagcaat aaaattctca ccttcaccca
1681 ggcccactga gtgtcagatt tgcatgcact agttcacgtg tgtaaaaagg aggatgcttc
1741 tttcctttgt attctcacat acctttagga aagaacttag cacccttccc acacagccat
1801 cccaataact catttcagtg actcaaccct tgactttata aaagtcttgg gcagtataga
1861 gcagagatta agagtacaga tgctggagcc agaccacctg agtgattagt gactcagttt
1921 ctcttagtaa ttgtatgact cagtttcttc atctgtaaaa tggagggttt tttaattagt
1981 ttgtttttga gaaagggtct cactctgtca cccaaatggg agtgtagtgg caaaatctcg
2041 gctcactgca acttgcactt cccaggctca agcggtcctc ccacctcaac atcctgagta
2101 gctggaacca caggtacaca ccaccatacc tcgctaattt tttgtatttt tggtagagat
2161 ggggtttcac atgttacaca ggatggtctc agactccgga gctcaagcaa tctgcccacc
2221 tcagccttcc aaagtgctgg gattataagc atgattacag gagttttaac aggctcataa
2281 gattgttctg cagcccgagt gagttaatac atgcaaagag tttaaagcag tgacttataa
2341 atgctaacta ctctagaaat gtttgctagt attttttgtt taactgcaat cattcttgct
2401 gcaggtgaaa actagtgttc tgtactttat gcccattcat ctttaactgt aataataaaa
2461 ataactgaca tttattgaag gctatcagag actgtaatta gtgctttgca taattaatca
2521 tatttaatac tcttggattc tttcaggtag atactattat tatccccatt ttactacagt
2581 taaaaaaact acctctcaac ttgctcaagc atacactctc acacacacaa acataaacta
2641 ctagcaaata gtagaattga gatttggtcc taattatgtc tttgctcact atccaataaa
2701 tatttattga catgtacttc ttggcagtct gtatgctgga tgctggggat acaaagatgt
2761 ttaaatttaa gctccagtct ctgcttccaa aggcctccca ggccaagtta tccattcaga
2821 aagcattttt tactctttgc attccactgt ttttcctaag tgactaaaaa attacacttt
2881 attcgtctgt gtcctgctct gggatgatag tctgactttc ctaacctgag cctaacatcc
2941 ctgacatcag gaaagactac accatgtgga gaaggggtgg tggttttgat tgctgctgtc
3001 ttcagttaga tggttaactt tgtgaagttg aaaactgtgg ctctctggtt gactgttaga
3061 gttctggcac ttgtcactat gcctattatt taacaaatgc atgaatgctt cagaatatgg
3121 gaatattatc ttctggaata gggaatcaag ttatattatg taacccagga ttagaagatt
3181 cttctgtgtg taagaatttc ataaacatta agctgtctag caaaagcaag ggcttggaaa
3241 atctgtgagc tcctcaccat atagaaagct tttaacccat cattgaataa atccctatag
3301 gggatttcta ccctgagcaa aaggctggtc ttgattaatt cccaaactca tatagctctg
3361 agaaagtcta tgctgttaac gttttcttgt ctgctacccc atcatatgca caacaataaa
3421 tgcaggccta ggcatgactg aaggctctct cataattctt ggttgcatga atcagattat
3481 caacagaaat gttgagacaa actatgggga agcagggtat gaaagagctc tgaatgaaat
3541 ggaaaccgca atgcttcctg cccattcagg gctccagcat gtagaaatct ggggctttgt
3601 gaagactggc ttaaaatcag aagccccatt ggataagagt agggaagaac ctagagccta
3661 cgctgagcag gtttccttca tgtgacaggg agcctcctgc cccgaacttc cagggatcct
3721 ctcttaagtg tttcctgctg gaatctcctc acttctatct ggaaatggtt tctccacagt
3781 ccagcccctg gctagttgaa agagttaccc atgcagaggc cctcctagca tccagagact
3841 agtgcttaga ttcctacttt cagcgttgga caacctggat ccacttgccc agtgttcttc
3901 cttagttcct accttcgacc ttgatcctcc tttatcttcc tgaaccctgc tgagatgatc
3961 tatgtgggga gaatggcttc tttgagaaac atcttcttcg ttagtggcct gcccctcatt
4021 cccactttaa tatccagaat cactataaga agaatataat aagaggaata actcttatta
4081 taggtaaggg aaaattaaga ggcatacgtg atgggatgag taagagagga gagggaagga
4141 ttaatggatg ataaaatcta ctactatttg ttgagacctt ttatagtcta atcaattttg
4201 ctattgtttt ccatcctcac gctaactcca taaaaaaaca ctattattat ctttattttg
4261 ccatgacaag actgagctca gaagagtcaa gcatttgcct aaggtcggac atgtcagagg
4321 cagtgccaga cctatgtgag actctgcagc tactgctcat gggccctgtg ctgcactgat
4381 gaggaggatc agatggatgg ggcaatgaag caaaggaatc attctgtgga taaaggagac
4441 agccatgaag aagtctatga ctgtaaattt gggagcagga gtctctaagg acttggattt
4501 caaggaattt tgactcagca aacacaagac cctcacggtg actttgcgag ctggtgtgcc
4561 agatgtgtct atcagaggtt ccagggaggg tggggtgggg tcagggctgg ccaccagcta
4621 tcagggccca gatgggttat aggctggcag gctcagatag gtggttaggt caggttggtg
4681 gtgctgggtg gagtccatga ctcccaggag ccaggagaga tagaccatga gtagagggca
4741 gacatgggaa aggtggggga ggcacagcat agcagcattt ttcattctac tactacatgg
4801 gactgctccc ctataccccc agctaggggc aagtgccttg actcctatgt tttcaggatc
4861 atcatctata aagtaagagt aataattgtg tctatctcat agggttatta tgaggatcaa
4921 aggagatgca cactctctgg accagtggcc taacagttca ggacagagct atgggcttcc
4981 tatgtatggg tcagtggtct caatgtagca ggcaagttcc agaagatagc atcaaccact
5041 gttagagata tactgccagt ctcagagcct gatgttaatt tagcaatggg ctgggaccct
5101 cctccagtag aaccttctaa ccagctgctg cagtcaaagt cgaatgcagc tggttagact
5161 ttttttaatg aaagcttagc tttcattaaa gattaagctc ctaagcaggg cacagatgaa
5221 attgtctaac agcaactttg ccatctaaaa aaatctgact tcactggaaa catggaagcc
5281 caaggttctg aacatgagaa atttttagga atctgcacag gagttgagag ggaaacaaga
5341 tggtgaaggg actagaaacc acatgagaga cacgaggaaa tagtgtagat ttaggctgga
5401 ggtaaatgaa agagaagtgg gaattaatac ttactgaaat ctttctatat gtcaggtgcc
5461 attttatgat atttaataat ctcattacat atggtaattc tgtgagatat gtattattga
5521 acatactata attaatacta atgataagta acacctcttg agtacttagt atatgctaga
5581 atcaaattta agtttatcat atgaggccgg gcacggtggc tcatatatgg gattacatgc
5641 ctgtaatccc agcactttgg gaggccaagg caattggatc acctgaggtc aggagttcca
5701 gaccagcctg gccaacatgg tgaaacccct tctctactaa aaaatacaaa aaatcagcca
5761 ggtgtggtgg cacgcgtcta taatcccagc tactcaggag gctgaggcag gagaatcact
5821 tgaacccagg aggtggaggt tgcagtgagc taagattgca ccactgcact ccagcctagg
5881 cgacagagtg agactccatc tcaaaaaaaa aaaaagaagt ttattatatg aattaactta
5941 gttttactca caccaatact cagaagtaga ttattacctc atttattgat gaggagccca
6001 atgtacttgt agtgtagatc aacttattga aagcacaagc taataagtag acaattagta
6061 attagaagtc agatggtctg agctctccta ctgtctacat tacatgagct cttattaact
6121 ggggactcga aaatcaaaga catgaaataa tttgtccaag cttacagaac caccaagtag
6181 taaggctagg atgtagaccc agttctgcta cctctgaaga cagtgttttt tccacagcaa
6241 aacacaaact cagatattgt ggatgcgaga aattagaagt agatattcct gccctgtggc
6301 ccttgcttct tacttttact tcttggcgat tggaagttgt ggtccaagcc acagttgcag
6361 accatacttc ctcaaccata attgcatttc ttcaggaaag tttgagggag aaaaaggtaa
6421 agaaaaattt agaaacaact tcagaataaa gagattttct cttgggttac agagattgtc
6481 atatgacaaa ttataagcag acacttgaga aaactgaagg cccatgcctg cccaaattac
6541 cctttgaccc cttggtcaag ctgcaacttt ggttaaaggg agtgtttatg tgttatagtg
6601 ttcatttact cttctggtct aacccattgg ctccgtcttc atcctgcagt gacctcagtg
6661 cctcagaaac atacatatgt ttgtctagtt taagtttgtg tgaaattcta actagcgtca
6721 agaactgagg gccctaaact atgctaggaa tagtgctgtg gtgctgtgat aggtacacaa
6781 gaaatgagaa gaaactgcag attctctgca tctccctttg ccgggtctga caacaaagtt
6841 tccccaaatt ttaccaatgc aagccatttc tccatatgct aactacttta aaatcatttg
6901 gggcttcaca ttgtctttct catctgtaaa aagaatggaa gaactcattc ctacagaact
6961 ccctatgtct tccctgatgg gctagagttc ctctttctca aaaattagcc attattgtat
7021 ttccttctaa gccaaagctc agaggtcttg tattgcccag tgacatgcac actggtcaaa
7081 agtaggctaa gtagaagggt actttcacag gaacagagag caaaagaggt gggtgaatga
7141 gagggtaagt gagaaaagac aaatgagaag ttacaacatg atggcttgtt gtctaaatat
7201 ctcctaggga attattgtga gaggtctgaa tagtgttgta aaataagctg aatctgctgc
7261 ctaacattaa cagtcaagaa atacctccga ataactgtac ctccaattat tctttaaggt
7321 agcatgcaac tgtaatagtt gcatgtatat atttatcata atactgtaac agaaaacact
7381 tactgaatat atactgtgtc cctagttctt tacacaataa actaatctca tcctcataat
7441 tctattagct aatacatatt atcatcctat atttcagaga cttcaagaag ttaagcaact
7501 tgctcaagat catctaagaa gtaggtggta tttctgggct catttggccc ctcctaatct
7561 ctcatggcaa catggctgcc taaagtgttg attgccttaa ttcatcaggg atgggctcat
7621 actcactgca gaccttaact ggcatcctct tttcttatgt gatctgcctg accctagtag
7681 aacttatgaa atttctgatg agaaaggaga gaggagaaag gcagagctga ctgtgatgag
7741 tgatgaaggt gccttctcat ctgggtacca gtggggcctc taagactaag tcactctgtc
7801 tcactgtgtc ttagccagtt ccttacagct tgccctgatg ggagatagag aatgggtatc
7861 ctccaacaaa aaaataaatt ttcatttctc aaggtccaac ttatgttttc ttaattttta
7921 aaaaaatctt gaccattctc cactctctaa aataatccac agtgagagaa acattctttt
7981 cccccatccc ataaatacct ctattaaata tggaaaatct gggcatggtg tctcacacct
8041 gtaatcccag cactttggga ggctgaggtg ggtggactgc ttggagctca ggagttcaag
8101 accatcttgg acaacatggt gataccctgc ctctacaaaa agtacaaaaa ttagcctggc
8161 atggtggtgt gcacctgtaa tcccagctat tagggtggct gaggcaggag aattgcttga
8221 acccgggagg cggaggttgc agtgagctga gatcgtgcca ctgcactcca gcctggggga
8281 cagagcacat tataattaac tgttattttt tacttggact cttgtgggga ataagataca
8341 tgttttattc ttatttatga ttcaagcact gaaaatagtg tttagcatcc agcaggtgct
8401 tcaaaaccat ttgctgaatg attactatac tttttacaag ctcagctccc tctatccctt
8461 ccagcatcct catctctgat taaataagct tcagtttttc cttagttcct gttacatttc
8521 tgtgtgtctc cattagtgac ctcccatagt ccaagcatga gcagttctgg ccaggcccct
8581 gtcggggtca gtgccccacc cccgccttct ggttctgtgt aaccttctaa gcaaaccttc
8641 tggctcaagc acagcaatgc tgagtcatga tgagtcatgc tgaggcttag ggtgtgtgcc
8701 cagatgttct cagcctagag tgatgactcc tatctgggtc cccagcagga tgcttacagg
8761 gcagatggca aaaaaaagga gaagctgacc acctgactaa aactccacct caaacggcat
8821 cataaagaaa atggatgcct gagacagaat gtgacatatt ctagaatata ttatttcctg
8881 aatatatata tatatatata tacacatata cgtatatata tatatatata tatatttgtt
8941 gttatcaatt gccatagaat gattagttat tgtgaatcaa atatttatct tgcaggtggc
9001 ctctatacct agaagcggca gaatcaggct ttattaatac atgtgtatag atttttagga
9061 tctatacaca tgtattaata tgaaacaagg atatggaaga ggaaggcatg aaaacaggaa
9121 aagaaaacaa accttgtttg ccattttaag gcacccctgg acagctaggt ggcaaaaggc
9181 ctgtgctgtt agaggacaca tgctcacata cggggtcaga tctgacttgg ggtgctactg
9241 ggaagctctc atcttaagga tacatctcag gccagtcttg gtgcattagg aagatgtagg
9301 caactctgat cctgagagga aagaaacatt cctccaggag agctaaaagg gttcacctgt
9361 gtgggtaact gtgaaggact acaagaggat gaaaaacaat gacagacaga cataatgctt
9421 gtgggagaaa aaacaggagg tcaaggggat agagaaggct tccagaagaa tggctttgaa
9481 gctggcttct gtaggagttc acagtggcaa agatgtttca gaaatgtgac atgacttaag
9541 gaactataca aaaaggaaca aatttaagga gaggcagata aattagttca acagacatgc
9601 aaggaatttt cagatgaatg ttatgtctcc actgagcttc ttgaggttag cagctgtgag
9661 ggttttgcag gcccaggacc cattacagga cctcacgtat acttgacact gttttttgta
9721 ttcatttgtg aatgaatgac ctcttgtcag tctactcggt ttcgctgtga atgaatgatg
9781 tcttgtcagc ctacttggtt tcgctaagag cacagagaga agatttagtg atgctatgta
9841 aaaacttcct ttttggttca agtgtatgtt tgtgatagaa atgaagacag gctacatgat
9901 gcatatctaa cataaacaca aacattaaga aaggaaatca acctgaagag tatttataca
9961 gataacaaaa tacagagagt gagttaaatg tgtaataact gtggcacagg ctggaatatg
10021 agccatttaa atcacaaatt aattagaaaa aaaacagtgg ggaaaaaatt ccatggatgg
10081 gtctagaaag actagcattg ttttaggttg agtggcagtg tttaaagggt gatatcagac
10141 taaacttgaa atatgtggct aaataactag aatactcttt attttttcgt atcatgaata
10201 gcagatatag cttgatggcc ccatgcttgg tttaacatcc ttgctgttcc tgacatgaaa
10261 tccttaattt ttgacaaagg ggctattcat tttcatttta tattgggcct agaaattatg
10321 tagatggtcc tgaggaaaag tttatagctt gtctatttct ctctctaaca tagttgtcag
10381 cacaatgcct aggctatagg aagtactcaa agcttgttaa attgaattct atccttctta
10441 ttcaattcta cacatggagg aaaaactcat cagggatgga ggcacgcctc taaggaaggc
10501 aggtgtggct ctgcagtgtg attgggtact tgcaggacga agggtggggt gggagtggct
10561 aaccttccat tcctagtgca gaggtcacag cctaaacatc aaattccttg aggtgcggtg
10621 gctcactcct gtaatcacag cagtttggga cgccaaggtg ggcagatcac ttgaggtcag
10681 gagttggaca ccagcccagc caacatagtg aaacctggtc tctgcttaaa aatataaaaa
10741 ttagctggac gtggtgacgg gagcctgtaa tccaactact tgggaggctg aggcaggaga
10801 atcgcttgaa ccggggaggt ggagtttgca ctgagcagag atcatgccat tgcactccag
10861 cctccagagc gagactctgt ctaaagaaaa acgaaaacaa acaaacaaac aaacaaacaa
10921 aacccatcaa attccctgac cgaacagaat tctgtctgat tgttctctga cttatctacc
10981 attttccctc cttaaagaaa ctgtggaact tccttcagct agaggggcct ggctcagaag
11041 cctctggtca gcatccaaga aatacttgat gtcactttgg ctaaaggtat gatgtgtaga
11101 caagctccag agatggtttc tcatttccat atccacccac ccagctttcc aattttaaag
11161 ccaattctga ggtagagact gtgatgaaca aacaccttga caaaattcaa cccaaagact
11221 cactttgcct agcttcaaaa tccttactct gacatatact cacagccaga aattagcatg
11281 cactagagtg tgcatgagtg caacacacac acacaccaat tccatattct ctgtcagaaa
11341 atcctgttgg tttttcgtga aaggatgttt tcagaggctg accccttgcc ttcacctcca
11401 atgctaccac tctggtctaa gtcactgtca ccaccaccta aattatagct gttgactcat
11461 aacaatcttc ctgcttctac cactgcccca ctacaatttc ttcccaatat actatccaaa
11521 ttagtctttt caaaatgtaa gtcatatatg gtcacctctt tgttcaaagt cttctgatag
11581 tttcctatat catttataat aaaaccaaat ccttacaatt ctctacaata gttgttcatg
11641 catatattat gtttattaca gatacgcata tatatagctc tcatataaat aaatatatat
11701 atttatgtgt atgtgtgtag agtgtttttt cttacaactc tatgatgtag gtattattag
11761 tgtcccaaat tttataattt aggacttcta tgatctcatc ttttattctc cccttcaccg
11821 aatctcatcc tacattggcc ttattgatat tccttgaaaa ttctaagcat cttacatctt
11881 tagggtattt acatttgcca ttccctatgc cctaaatatt taatcatagt ttcatataaa
11941 tgggttcctc atcatctatg ggtactctct caggtgttaa ctttatagtg aggactttcc
12001 tgccatacta cttaaagtag cgataccctt tcaccctgtc ctaatcacac tctggccttc
12061 atttcagttt tttttttttc tccatagcac ctaatctcat tggtatataa catgtttcat
12121 ttgcttattt aatgtcaagc tctttccact atcaagtcca tgaaaacagg aactttattc
12181 ctctattctg tttttgtgct gtattcttag caattttaca attttgaatg aaatgaatga
12241 gcagtcaaac acatatacaa ctataattaa aaggatgtat gctgacacat ccactgctat
12301 gcacacacaa agaaatcagt ggagtagagc tggaagcgct aagcctgcat agagctagtt
12361 agccctccgc aggcagagcc ttgatgggat tactgagttc tagaattgga ctcatttgtt
12421 ttgtaggctg agatttgctc ttgaaaactt gttctgacca aaataaaagg ctcaaaagat
12481 gaatatcgaa accagggtgt tttttacact ggaatttata actagagcac tcatgtttat
12541 gtaagcaatt aattgtttca tcagtcaggt aaaagtaaag aaaaactgtg ccaaggcagg
12601 tagcctaatg caatatgcca ctaaagtaaa cattattcca taggtgtcag atatggctta
12661 ttcatccatc ttcatgggaa ggatggcctt ggcctggaca tcagtgttat gtgaggttca
12721 aaacacctct aggctataag gcaacagagc tccttttttt tttttctgtg ctttcctggc
12781 tgtccaaatc tctaatgata agcatacttc tattcaatga gaatattctg taagattata
12841 gttaagaatt gtgggagcca ttccgtctct tatagttaaa tttgagcttc ttttatgatc
12901 actgtttttt taatatgctt taagttctgg ggtacatgtg ccatggtggt ttgctgcacc
12961 catcaacccg tcatctacat taggtatttc tcctaatgct atccttcccc tagcccccca
13021 cccccaacag gccccagtgt gtgatgttcc cctccctgtg tccatggatc actggttttt
13081 tttttttttt tttttttttt tttaaagtct cagttaaatt tttggaatgt aatttatttt
13141 cctggtatcc taggacctgc aagttatctg gtcactttag ccctcacgtt ttgatgataa
13201 tcacatattt gtaaacacaa cacacacaca cacacacaca cacatatata tatataaaac
13261 atatatatac ataaacacac ataacatatt tatcgggcat ttctgagcaa ctaactcatg
13321 caggactctc aaacactaac ctatagcctt ttctatgtat ctacttgtgt agaaaccaag
13381 cgtggggact gagaaggcaa tagcaggagc attctgactc tcactgcctt tggctaggtc
13441 cctccctcat cacagctcag catagtccga gctcttatct atatccacac acagtttctg
13501 acgctgccca gctatcacca tcccaagtct aaagaaaaaa ataatgggtt tgcccatctc
13561 tgttgattag aaaacaaaac aaaataaaat aagcccctaa gctcccagaa aacatgacta
13621 aaccagcaag aagaagaaaa tacaataggt atatgaggag actggtgaca ctagtgtctg
13681 aatgaggctt gagtacagaa aagaggctct agcagcatag tggtttagag gagatgtttc
13741 tttccttcac agatgcctta gcctcaataa gcttgcggtt gtggaagttt actttcagaa
13801 caaactcctg tggggctaga attattgatg gctaaaagaa gcccggggga gggaaaaatc
13861 attcagcatc ctcaccctta gtgacacaaa acagaggggg cctggttttc catatttcct
13921 catgatggat gatctcgtta atgaaggtgg tctgacgaga tcattgcttc ttccatttaa
13981 gccttgctca cttgccaatc ctcagtttta accttctcca gagaaataca cattttttat
14041 tcaggaaaca tactatgtta tagtttcaat actaaataat caaagtactg aagatagcat
14101 gcataggcaa gaaaaagtcc ttagctttat gttgctgttg tttcagaatt taaaaaagat
14161 caccaagtca aggacttctc agttctagca ctagaggtgg aatcttagca tataatcaga
14221 ggtttttcaa aatttctaga catgagattc aaagccctgc acttaaaata gtctcatttg
14281 aattaactct ttatataaat tgaaagcaca ttctgaacta cttcagagta ttgttttatt
14341 tctatgttct tagttcataa atacattagg caatgcaatt taattaaaaa aacccaagaa
14401 tttcttagaa ttttaatcat gaaaataaat gaaggcatct ttacttactc aaggtcccaa
14461 aaggtcaaag aaaccaggaa agtaaagcta tatttcagcg gaaaatggga tatttatgag
14521 ttttctaagt tgacagactc aagttttaac cttcagtgcc catgatgtag gaaagtgtgg
14581 cataactggc tgattctggc tttctactcc tttttcccat taaagatccc tcctgcttaa
14641 ttaacattca caagtaactc tggttgtact ttaggcacag tggctcccga ggtcagtcac
14701 acaataggat gtctgtgctc caagttgcca gagagagaga ttactcttga gaatgagcct
14761 cagccctggc tcaaactcac ctgcaaactt cgtgagagat gaggcagagg tacactacga
14821 aagcaacagt tagaagctaa atgatgagaa cacatggact catagaggga aacaacgcat
14881 actggggcct atcagagggt ggagggtgag agaaggagag gatcaggaaa aatcactaat
14941 ggatgctaag cgtaatacct gagtgatgag atcatctata caacaaaccc ccttgacatt
15001 catttatcta tgtaacaaac ctgcacatcc tgtacacgta cccctgaact taaaataaaa
15061 gttgaaaaca agaaagcaac agtttgaaca cttgttatgg tctattctct cattctttac
15121 aattacacta gaaaatagcc acaggctcct gcaaggcagc cacagaattt atgacttgtg
15181 atatccaagt cattcctgga taatgcaaaa tctaacacaa aatctagtag aatcatttgc
15241 ttacatctat ttttgttctg agaatataga tttagataca taatggaagc agaataattt
15301 aaaatctggc taatttagaa tcctaagcag ctcttttcct atcagtggtt tacaagcctt
15361 gtttatattt ttcctatttt aaaaataaaa ataaagtaag ttatttgtgg taaagaatat
15421 tcattaaagt atttatttct tagataatac catgaaaaac attcagtgaa gtgaagggcc
15481 tactttaccc aacaagaatc taatttatat aatttttcat actaatagca tctaagaaca
15541 gtacaatatt tgactcttca ggttaaacat atgtcataaa ttagccagaa agatttaaga
15601 aaatattgga tgtttccttg tttaaattag gcatcttaca gtttttagaa tcctgcatag
15661 aacttaagaa attacaaatg ctaaagcaaa cccaaacagg caggaattaa tcttcatcga
15721 atttgggtgt ttctttctaa aagtccttta tacttaaatg tcttaagaca tacatagatt
15781 ttattttact aattttaatt atacagacaa taaatgaata ttcttactga ttactttttc
15841 tgactgtcta atctttctga tctatcctgg atggccataa cacttatctc tctgaacttt
15901 gggcttttaa tataggaaag aaaagcaata atccattttt catggtatct catatgataa
15961 acaaataaaa tgcttaaaaa tgagcaggtg aagcaattta tcttgaacca acaagcatcg
16021 aagcaataat gagactgccc gcagcctacc tgacttctga gtcaggattt ataagccttg
16081 ttactgagac acaaacctgg gcctttcaat gctataacct ttcttgaagc tcctccctac
16141 cacctttagc cataaggaaa catggaatgg gtcagatccc tggatgcaag ccaggtctgg
16201 aaccataggc agtaaggaga gaagaaaatg tgggctctgc aactggctcc gagggagcag
16261 gagagaatca accccatact ctgaatctaa gagaagactg gtgtccatac tctgaatggg
16321 aagaatgatg ggattaccca tagggcttgt tttagggaga aacctgttct ccaaactctt
16381 ggccttgaga tacctggtcc ttattccttg gactttggca atgtctgacc ctcacattca
16441 agttctgagg aagggccact gccttcatac tgtggatctg tagcaaattc cccctgaaaa
16501 cccagagctg tatcttaatt gtttaaaaaa attatattat ctcaaggact gttcttctct
16561 gagtagccaa gctcagcttg gttcaagcta caagcagctg cgctgctttt tgtctagtca
16621 ttgttctttt atttcagtgg atcaaatacg ttctttccaa acctaggatc ttgtcttcct
16681 ggactatata ttttatccac gaagtcttaa tctggggtcc acagaacact agggggctgg
16741 tgaagtttat agaaaaaaaa tctgtatttt tacttacatg taactgaaat ttagcatttt
16801 cttctacttt gaatgcaaag gacaaactag aatgacatca tcagtaccta ttgcatagtt
16861 ataaagagaa accacagata ttttcatact acaccatagg tattgcagat ctttttgttt
16921 ttgtttttgt ttgagatgga gtttcgctct tattgcccag gctggagtgc agtggcatga
16981 tttcggctca ctgcaacctc cccttcctgc attcaagcaa ttctcctgcc ttggcctcca
17041 gagtagctgg ggattacagg cacctgccac catgccagtc taatttttgt atttttagta
17101 gagaatgggt ttcgccatgt tggccaggct ggtcttgaac tcctgacctc agatgatctg
17161 cccgccttgg cctcctgaag tgctgggatt ataggtgtga gccaccacgc ctggcccatt
17221 gcagatattt ttaattcaca tttatctgca tcactacttg gatcttaagg tagctgcaga
17281 cccaatccca gatctaatgc tttcataaag aagcaaatat aataaatact ataccacaaa
17341 tgtaatgttt gatgtctgat aatgatattt cagtgtaatt aaacttagca ctccatgtat
17401 attatttgat gcaataaaaa catatttttt tagcacttac agtctgccaa actggcctgt
17461 gacacaaaaa aagtttaggg gaattcccct agttttgtct gtgttagcca atggttagaa
17521 tatatgctca gaaagatacc attggttaat agctaaaaga aaatggagta gaaattcagt
17581 ggcctggaat aataacaatt tgggcagtca ttaagtcagg tgaagacttc tggaatcatg
17641 ggagaaaagc aagggagaca ttcttacttg ccacaagtgt tttttttttt tttttttttt
17701 atcacaaaca taagaaaata taataaataa caaagtcagg ttatagaaga gagaaacgct
17761 cttagtaaac ttggaatatg gaatccccaa aggcacttga cttgggagac aggagccata
17821 ctgctaagtg aaaaagacga agaacctcta gggcctgaac atacaggaaa ttgtaggaac
17881 agaaattcct agatctggtg gggcaagggg agccatagga gaaagaaatg gtagaaatgg
17941 atggagacgg aggcagaggt gggcagatca tgaggtcaag agatcgagac catcctggca
18001 aacatggtga aatcccgtct ctactaaaaa taaaaaaatt agctgggcat ggtggcatgc
18061 gcctgtagtc ccagctgctc gggaggctga ggcaggagaa tcgtttgaac ccaggaggcg
18121 aaggttgcag tgagctgaga tagtgccatt gcactccagt ctggcaacag agtgagactc
18181 cgtctcaaaa aaaaaaaaaa gaaagaaaga aaagaaaaag aaaaaagaaa aaataaatgg
18241 atgtagaaca agccagaagg aggaactggg ctggggcaat gagattatgg tgatgtaagg
18301 gacttttata gaattaacaa tgctggaatt tgtggaactc tgcttctatt attcccccaa
18361 tcattacttc tgtcacattg atagttaaat aatttctgtg aatttattcc ttgantccca
18421 aaatattgag gtaaataaca atggtattat aaaagggcag attaagtgat atagcataag
18481 caatattctt caggcacatg gatcgaattg aatacactgt aaatcccaac ttccagtttc
18541 agctctacca agtaaagagc tagcaagtca tcaaaatggg gacatacaga aaaaaaaaag
18601 gacactagag gaataatata ccctgactcc tagcctgatt aatatatcga ttcactttta
18661 ctctgtttgg tgacaaattc tggctttaaa taattttagg attttaggct tctcagctcc
18721 cttcccagtg agaagtataa gcaggacagc aggcaagcaa gaagagagcc caaggcaata
18781 ctcacaaagt agccagtgtc ccctgtggtc atagagaaat ggaaagagag aggantcccc
18841 ccttggagcc actgggtggt aatcctttcc gtccgttcct ctctagggaa tcaccccaag
18901 gtactgtact ttgggattaa ggctttagtc ccactgtgga ctacttgcta ttctgttcag
18961 tttctgaagg aactatgtac ggtttttgtc tccctagaga aactaaggta cagaagtttt
19021 gtttacaatg cactccttaa gagagctaga actgggtgaa gantcctggt ttaaccagcc
19081 ttaatttcct ttccctgggc cccggtttgg tcacgtcact gtcaccacct ttaaggcaaa
19141 tgttaaatgc gctttggctg aactttttcc tattttgaga tttgctcctt tatatgaggc
19201 tttcttggaa aaggagaatg ggagagatgg atatcatttt ggaagatgat gaagagggta
19261 aaaaagggta caaatggaaa tttgtgttgc agatagtatg aggagccaac aaaaaagagc
19321 ctcaggatcc agcacacatt atcacaaact tagtgtccat ccatcactgc tgaccctctc
19381 cggacctgac tccacccctg aggacacagg tcagccttga ccaatgactt ttaagtacca
19441 tggagaacag ggggccagaa cttcggcagt aaagaataaa aggccagaca gagaggcagc
19501 agcacatatc tgcttccgac acagctgcaa tcactagcaa gctctcaggc ctggcatcat
19561 ggtgcatttt actgctgagg agaaggctgc cgtcactagc ctgtggagca agatgaatgt
19621 ggaagaggct ggaggtgaag ccttgggcag gtaagcattg gttctcaatg catgggaatg
19681 aagggtgaat attaccctag caagttgatt gggaaagtcc tcaagatttt ttgcatctct
19741 aattttgtat ctgatatggt gtcatttcat agactcctcg ttgtttaccc ctggacccag
19801 agattttttg acagctttgg aaacctgtcg tctccctctg ccatcctggg caaccccaag
19861 gtcaaggccc atggcaagaa ggtgctgact tcctttggag atgctattaa aaacatggac
19921 aacctcaagc ccgcctttgc taagctgagt gagctgcact gtgacaagct gcatgtggat
19981 cctgagaact tcaaggtgag ttcaggtgct ggtgatgtga ttttttggct ttatattttg
20041 acattaattg aagctcataa tcttattgga aagaccaaca aagatctcag aaatcatggg
20101 tcgagcttga tgttagaaca gcagacttct agtgagcata accaaaactt acatgattca
20161 gaactagtga cagtaaagga ctactaacag cctgaattgg cttaactttt caggaaatct
20221 tgccagaact tgatgtgttt atcccagaga attgtattat agaattgtag acttgtgaaa
20281 gaagaatgaa atttggcttt tggtagatga aagtccattt caaggaaata gaaatgcctt
20341 attttatgtg ggtcatgata attgaggttt agaagagatt tttgcaaaaa aaataaaaga
20401 tttgctcaaa gaaaaataag acacattttc taaaatatgt taaatttccc atcagtattg
20461 tgaccaagtg aaggcttgtt tccgaatttg ttggggattt taaactcccg ctgagaactc
20521 ttgcagcact cacattctac atttacaaaa attagacaat tgcttaaaga aaaacaggga
20581 gagagggaac ccaataatac tggtaaaatg gggaaggggg tgagggtgta ggtaggtaga
20641 atgttgaatg tagggctcat agaataaaat tgaacctaag ctcatctgaa ttttttgggt
20701 gggcacaaac cttggaacag tttgaggtca gggttgtcta ggaatgtagg tataaagccg
20761 tttttgtttg tttgtttgtt ttttcatcaa gttgttttcg gaaacttcta ctcaacatgc
20821 ctgtgtgtta ttttgtcttt tgcctaacag ctcctgggta acgtgatggt gattattctg
20881 gctactcact ttggcaagga gttcacccct gaagtgcagg ctgcctggca gaagctggtg
20941 tctgctgtcg ccattgccct ggcccataag taccactgag ttctcttcca gtttgcaggt
21001 cttcctgtga ccctgacacc ctccttctgc acatggggac tgggcttggc cttgagagaa
21061 agccttctgt ttaataaagt acattttctt cagtaatcaa aaattgcaat tttatcttct
21121 ccatctttta ctcttgtgtt aaaaggaaaa agtgttcatg ggctgaggga tggagagaaa
21181 cataggaaga accaagagct tccttaagaa atgtatgggg gcttgtaaaa ttaatgtgga
21241 tgttatggga gaattcccaa gattcccaag gaggatgata tgatggagaa aaatctttat
21301 cggggtggga aaatggttaa ttaagtggca gagactccta ggcagttttt actgcaccgg
21361 ggaaagaagg agctgttgtg gtacctgaga aagcagattt gtggtacatg tcacttttca
21421 ttaaaaacaa aaacaaaaca aaacaaaact tcatagatat ccaagatata ggctgagaat
21481 tactatttta atttactctt atttacattt tgaagtagct agcttgtcac atgttttatg
21541 aaattgattt ggagataaga tgagtgtgta tcaacaatag cctgctcttt ccatgaagga
21601 ttccattatt tcatgggtta gctgaagcta agacacatga tatcattgtg cattatcttc
21661 tgatacaatg taacatgcac taaaataaag ttagagttag gacctgagtg ggaaagtttt
21721 tggagagtgt gatgaagact ttccgtggga gatagaatac taataaaggc ttaaattcta
21781 aaaccagcaa gctagggctt cgtgacttgc atgaaactgg ctctctggaa gtagaaggga
21841 gagtaagaca tacgtagagg actaggaaag accagatagt acagggcctg gctacaaaaa
21901 tacaagcttt tactatgcta ttgcaatact aaacgataag cattaggatg ttaagtgact
21961 caggaaataa gattttggga aaaagtaatc tgcttatgtg cacaaaatgg attcaagttt
22021 gcagataaaa taaaatatgg atgatgattc aaggggacag atacaatggt tcaaacccaa
22081 gaggagcagt gagtctgtgg aattttgaag gatggacaaa ggtggggtga gaaagacata
22141 gtattcgacc tgactgtggg agatgagaag gaagaaggag gtgataaatg actgaaagct
22201 cccagactgg tgaagataac aggaggaaac catgcacttg accctggtga ctctcatgtg
22261 tgaagggtag agggatatta acagatttac tttttaggaa gtgctagatt ggtcagggag
22321 ttttgacctt caggtcttgt gtctttcata tcaaggaacc tttgcatttt ccaagttaga
22381 gtgccatatt ttggcaaata taactttatt agtaatttta tagtgctctc acattgatca
22441 gactttttcc tgtgaattac ttttgaattt ggctgtatat atccagaata tgggagagag
22501 acaaataatt attgtagttg caggctatca acaatactgg tctctctgag ccttataacc
22561 tttcaatatg ccccataaac agagtaaaca gggattattc atggcactaa atattttcac
22621 ctaggtcagt caacaaatgg aggcaatgtg cattttttga tacatatttt tatatattta
22681 tggggcatgt gatacttaca tgcctagaac atgtgactga ttaagtctag atatttagga
22741 tatccattac tttgagcatt tatcatttct atgtattgag aaaatttcaa atcctcattt
22801 ctgaccattt tgaaatatat aataaatagt aattaactat agtcacccta ctcaaatatc
22861 aacattataa actaactaat ccttctttcc acttttttac caaccaacat ctcttaaatc
22921 ccctgccata cacatcacac atttttcagc tctgataact atcattctac tctcatacca
22981 ccatgagacc acttttttag ctccacagat gaataaaaac atgtgatatt tgactttctg
23041 tatctggctt attttattat ctatctcttt ggcataccaa gagtttgttt ttgttctgct
23101 tcagggcttt caattaacat aatgacctct ggttccatcc atgttgctac aaatgacaag
23161 atttcattct ttttcatggc aaaatagtac tgtgcaaaaa atacaatttt ttaatccgtt
23221 catctgttga tagacactta ggttgatccc aaaccttaac tattgtgaat aggtgcttca
23281 ataaacatga gtgtaatgtg tccattggat atactgattt cctttctttt ggataaataa
23341 ccactagtga gattgctgga ttgtatgata gttctgtttt tagtttattg agaaatcttc
23401 atactgtttt ccataatggt tgtactattt tacattccca ccaacagtgt gtaagaaaga
23461 gttccctttt ctccatatcc tcacaaggat ctgttatttt ttgtcttttt tgttaatagc
23521 attttaacta gagtaagtag atatctcatt gtagttttga tttgcatttc cctgatcatt
23581 agtgatgttg agattttttc atatgtttgt tggtcatttg tatatctttt tctgagattg
23641 tctgttcatg tccttatcct acttttattg ggattgttgt tattttcttg ataatcattg
23701 tgtcatttta gagcctggat attattcttt tgtcagatgt atagattgtg aagattttct
23761 cctctgtggg ttgtctgttt attctgcaga ctcttccttt tgccatgcaa aagctcttta
23821 gtttaattta gtcccagata ttttctttgt ttttatgtgt ttgcatttgt gttcttgtca
23881 tgaaatcctt tcctaagcca atgtgtagaa gggtttttcc gatgttattt tctagaattg
23941 ttacagtttc aggcttagat ttaagtcctt gatccatctt aagttgattt ttgtataagg
24001 tgagagatga agatccagtt tcattctcct acatgtagct tgccagctat cccgactcat
24061 ttgttgaata gggtgccctt tcccatttat gtttttgttt gctttgtcaa agatcagttc
24121 ggatgtaagt atttgagttt atttctgggt tctctattct gttccattgg tccgatgtgc
24181 ctatttgtac accagcatca tgctgtgttt ttggtgacta tggccttatt gtatagtttg
24241 aaatgaggta atgtaatgcc attcagattt gttctttttt ttagacttgc ttgtttattg
24301 ggctcttttt tggttccata agaattttag gattgttttt tctagttctg tgaaggctaa
24361 tggtggtatt tatgggaatt gcaatgcaat ttgtaggttg cttctggcat tatggccatt
24421 ttcacaatat tgattctacc catctatgag aatggcatgt gtttccattt gtttgtgtct
24481 tatatgatta ctatcagccg tgttttgtag ttttccttgt agatgtcttt cacctccttg
24541 gttaggtata tattcctaag tttttgtttt gttttgtttt gttttttgca gctattgtaa
24601 aaggggttga gttattgatt ttattctcat cttggtcatt gctggtatgt aagaaagcaa
24661 ctcattggtg tacgttaatt ttgtatccag aaactttgct gaattatttt atcagttcta
24721 gggggttttg gaggagtctt tagagttttc tacatacaca atcatatcat cagcaaacag
24781 tgacagtttg actttctctt taacaatttg gatgtgcttt acttgtttct cttgtctgat
24841 tgctcttgct aggacttcca gtaatatgtt aaagagaagt ggtgagagtg ggtatccttg
24901 tctcattcca gttttcagac agaatgcttt taactttttc ccattcaata taatgttggc
24961 tgtgtgttta ccatagctgg cttttattac attgaggtat gtcctttgta aaccgatttt
25021 gctgagtttt agtcataaag tgatgttgaa ttttgttgaa tgcagtttct gtggctattg
25081 agataatcac atgatttttg tttccaattc tctttatgtt gtgtatcaca cttattgact
25141 tgcgtatgtt aaaccatccg tgcatccctc gcatgaaacc acttgatcat gggttttgat
25201 atgccgtgtg ggatgctatt agctatattt tgtcaaggat gttggcatct atgttcatca
25261 gggatattga tctgtagtgt tttttttttt tggttatgtt ctttcccagt tttggtatta
25321 aggtgatact ggcttcatag aatgatttag ggaggattct ctctttctct atcttgtaga
25381 atactgtcaa taggattggt atcaattctt ctttgaatgt ctggtagaat tcgaacgtct
25441 cctttaggtt ttctagttta ttcatgtaaa ggtgttcata gtaaccttga ataatctttt
25501 gtatttctgt ggtatcagta atagtatctc ctgttttgtt tctaactgag tttatttgca
25561 cttctctcct cttttcttgg ttaatcttgc taatggtcta tcagttttat ttatcttttc
25621 aaagaaccag ctttttattt catttagctt ttgtattttt ttgcagttgt tttaatttca
25681 tttagttctc ctcttatctt agttattccc tttcttttgc tgggttttgg ttctgtttgt
25741 ttttgtttct ctagtttctt gtggtgtgac cttatattgt ctgtcctctt tcagactctt
25801 tgacatcgac atttagggct gtgaactttc cttttagcac catctttgct gtatcctaga
25861 ggttttgata ggtgtgtcac tattgtcggt cagttcaagt aattttgttg ttcttattat
25921 actttaagtt ctgggataca tgtgcagaat gtgcaggttt gttacatagg tatagatgtg
25981 ccatggtggt ttgctgctcc catcaacctg tcatctacat taggtatttc ttttaatgtt
26041 atccctctcc taaccccctc accccccgac aggccctggt gtgtgatgtt cccctccctg
26101 tgtccatgtg ttctcattgt tcaactccca cttatgagtg agaacgtgtg gtgtttggtt
26161 tctctgttcc tgtgttagtt tgctcagaat gatgtttcca ccttcaccat gtccctgcaa
26221 agacatgaac tcatcatttt atggctgcat atattccatg gtgtatatgt gccacatttt
26281 ctttatccat tatatcgctg atggccattt gggttggttc caagtctttg gtattgtgaa
26341 tagtgccgca ataaacatac gtgtgcacat gtctttatag tagaatgatt tctaattctt
26401 tgggtatata cccagtaatg ggattgctgg gtcaaacagt atttctggtt ctagatcctt
26461 gaggaattgc cacactgtct tccacaatgg ttgaactaat ttacacaccc atcaacagtg
26521 taaaattttt cctattcttc cacatcctct ccagcacctt ttgtttcctg actttttaat
26581 aattgccatt ctaactggca tgagatggta tctcattgtg gttttgattt gcatttctct
26641 aatgaccagt gatgatgagc ttcttttcat gtgtttcttg gccacataaa tgacttcttt
26701 agagaagcat ctgttcatat cctttgtcca ctttttgatg gggtcgttag gttttttctt
26761 gtaaatttgt tgaagttctt tgtagatttt ggatgttagc cctttgtcag atggatagat
26821 tggcaaaaat tttctcccat tctgtaggtt gcctgttcac tctgatgata gtcttttgct
26881 gtgcagaagc tctttagttt aattagatcc catatgtcaa ttttggcctt tgttgtcatt
26941 gcttttgatg tttagtcgtg gaattttgcc catgcctatg tcctgaatgg tattgcctag
27001 gttatcttct aggattttta tggttttagg ttgcacattt aagtctttaa tccaccttga
27061 gttaattttt gtataaggtg taaggaaggg gtacagtttc agttttatgc atattgctag
27121 ccagtttttc cagcaccatt tattaaatag ggaattcttt ctccattgct tttgtgatgt
27181 ttgtcaaaga tcagatggtc gtagatgtgt ggcattattt ctgaggcttc tgttctgttc
27241 cactggtcta tatatctgtt ttggtaccag taccatgctg tttttgttac tgtagccttg
27301 tagtatagct tgaagtcagg tagcatcatg cctccagctt tgttcttttt gtttaggatt
27361 gtcttggcta tatgggctct tttttgattc catatgacat ttaaagtagt tttttctaat
27421 tctttgaaaa aagtcagtgg tagcttgatg gggatagcat tgaatctata aattactttg
27481 ggcagtatgg ccattttaaa gatattgatt ctttctatct atgagcatgg aatgtttttc
27541 catttgtttg tgtcctctct tatttccttg agcagtgagt ggtttgtagc tctccttgaa
27601 gaggttcttc acatccctta taagttgtat ttctaggtat tttattttat tctctttgca
27661 gcaattgtga atgggagttc acccatgatt tggctctctg cttgtctatt attggtgtat
27721 aggaatgctt gtgatttttg cacactgatt ttgtatcttg agactttgct gaagctgttt
27781 atcagcttaa gattttgggc tgagatgaca gggtcttcta aatatacaat catgtcatct
27841 gcaaacagag acaatttgac ttcctctctt cctatttgaa tatgctttat ttctttctct
27901 tgcctgattg tcctggcgag aacttccaat actatgttga gtaagagtgg cgagagggca
27961 tccttgtctt gtgccggttt tcaaagcaaa tgatttttaa atttccgtct tgatttcatt
28021 gttgacccaa tgatcattca ggagcaggtt atttaatttc cctgtatttg catggttttg
28081 aaggttcctt ttgtagttga tttccaattt tattctactg tggtctgaga gagtgcttga
28141 tataatttca atttttaaaa atttattgag gcttgttttg tggcatatca tatggcctat
28201 cttggagaaa gttccatgtg ctgatgaata gaatgtgtat tctgcagttg ttgggtagaa
28261 tgtcctgtaa atatctgtta agtccatttg ttctttaaat ccattgtttc tttgtagact
28321 gtcttgatga cctgcctagt gcagtcagtg gagtattgaa gtcccccact attattatgt
28381 tgctgtctag tagtaattgt tttataaatt tgggatctcc agtattagat gcatatatat
28441 taagaattgt aatattctcc cattggacaa gggcttttat cattatatga tgtccctctt
28501 tgtctttttt aactgctgtt tctttaaagt ttgttttgtc tgacataaga atagctgctt
28561 tggctcgctt ttggtgtcca tttgtgtgga atgtcatttt ccaccccttt accttaagtt
28621 tatgtgagtc cttatgtgtt aggtgagtct cctgaaggcg gcagataact ggttggtgaa
28681 ttctattcat tctgcaattc tgtatctttt aagtggagca tttagtccat ttacattcaa
28741 catcagtatt gaggtgtgag gtgactattc cattcttcgt ggtatttgtt gcctgtgtat
28801 ctttttatct gtatttttgt tgtatatgtc ctatgggatt tatgctttaa agaggttctg
28861 ttttgatgtg cttccagggt ttatttcaag atttagagct ccttttatca ttcttgtagt
28921 gttggcttgg tagtgccgaa ttctctcagc atttgttttt ctgaaaaaca ctgtgtattt
28981 tcttcatttg tgaagcttag tttcactgga tataaaattc ttggctgata attgttttgt
29041 ttaagaaggc tgaagatagg gccatattca cttctagctt ttacggtttc tgctgagaaa
29101 tctgctgtta atctgatagg ttttctttca taggttacct ggtagtttca cctcacagct
29161 cttaagattc tctttgtctt tagataactt tggatactct gatgacaatg tacctaggca
29221 atgatatttt tgcaatgaat ttcccaggtg tttattgagc ttctttgtat ttggatatct
29281 aggtctctag caaggagggg gaagttttcc ttgattattt ccatggacaa gttttccaaa
29341 cttttagatt tctcttcttt ctcaggaatg ctgattattc ttaggtttga ttgtttaaca
29401 taatcccaga tttcttggag gctttgttca tattttctta ttcttttttc tttgtctttg
29461 ttggattggg taattcaaaa actttgtctt caagctctga atttcttctg cttggattct
29521 attgctgaga ctttctagag cattttgcat ttctataagt gcatccattc atccattgtt
29581 tcctgaagtt ttgaatgttt tttatttatg ctatctcttt aactgaagat ttctcccctc
29641 atttcttgta tcatattttt ggttttttta aaattggact tcaccttcct cggatgcctc
29701 cttgattagc ttaataactg accttctgaa ttatttttca ggtaaatcag ggatttcttc
29761 ttggtttgga tgcattgctg gtgagctagt atgatttttt ggggggtgtt aaagaacctt
29821 gtttttcata ttaccagagt tagttttctg gttccttctc acttgggtag gctctgtcag
29881 agggaaagtc taggcctcaa ggctgagact tttgtcccag caggtgttcc cttgatgtag
29941 cacagtcccc cttttcctag gacgtggggc ttcctgagag ccgaactgta gtgattgtta
30001 tctctcttct ggatctagcc acccatcagg tctaccagac tccaggctgg tactggggtt
30061 tgtctgcaca gagtcttgtg acgtgaacca tctgtgggtc tctcagccat agatacaacc
30121 acctgctcca atggaggtgg tagaggatga aatgaactct gtgagggtcc ttacttttgg
30181 ttgttcaatg cactatcttt ttgtgctggt tggcctcctg ccaggaggtg gcactttcta
30241 gaaagcatca gcagaggcag tcaggtggtg gtggctgggg gggctggggc actagaactc
30301 ccaagaatat atgccctttg tcttcagcta ctagggtgag taaggaagga ccatcaggtg
30361 ggggcaggac tagtcgtgtc tgagctcaga gtctccttgg gcaggtcttt ctgtggctac
30421 tgtgggagga tgggggtgta gtttccaggt caatggattt atgttcctag gacaattatg
30481 gctgcctctg ctgtgtcatg caggtcatca ggaaagtggg ggaaagcaag cagtcacgtg
30541 acttgcccag ctcccatgca actcaaaagg ttggtctcac ttccagcgtg caccctcccc
30601 cgcaacagct ccgaatctgt ttccatgcag tcagtgagca aggctgagaa cttgcccagg
30661 ctaccagctg cgaaaccaag tagggctgtc ctacttccct gccagtggag tctgcacacc
30721 aaattcatgt ccccccacca acccccccac tgcccagccc ctagatctgg ccaggtggag
30781 attttctttt tcctgtctct tttcccagtt cctctggcag ccctcccaaa tgacccctgt
30841 gaggcaaggc agaaatggct tcctagggga cccagagagc ccacagggct tttcccgctg
30901 cttcctctac ccctgtattt tgcttggccc tctaaattga ctcagctcca ggtaaggtca
30961 gaatcttctc ctgtggtcta gatcttcagg ttcccagtga ggatgtgtgt ttgggggtag
31021 acggtccccc ttttccactt ccacagtttg ggcactcaca atatttgggg tgtttcccgg
31081 gtcctacatg agcaatctgc ttctttcaga gggtgtgtgc gttctctcag ctttcttgaa
31141 tttatttctg caggtggttc tgcaaaaaaa attcctgatg ggagacttca catgctgctc
31201 tgtgcatccg agtgggagct gcaatgtact tctgctgcca cccatctgcc atcaccctct
31261 aatttgtcgg taatatgcat ttttaatcaa tctttttttc tctctctctc ttttcttctc
31321 ccccaaaact atactgccct ttgatatcaa ggaatcaagg ccgtgatgtt gaggggtggg
31381 cagtggatac actctttacc ccttagggag catatctaga tttagatatt gccaattcaa
31441 gataacttaa ttgaaagcaa attcataatg aatacacaca cacacacaca catctgcatg
31501 acaagatttt taatagttga aagaataact aataattgtc cacaggcaat aagggctttt
31561 taagcaaaac agttgtgata aaacaggtca ttcttagaat agtaatccag ccaatagtac
31621 aggttgctta gagattatga cattaccaga gttaaaattc aataatggct tctcactccc
31681 taccactgag gacaagttta tgtccttagg tttatgcttc cctgaaacaa taccacctgc
31741 tattctccac tttacatatc aacggcactg gttctttatc taactctctg gcacagcagg
31801 agtttgtttt cttctgcttc agagctttga atttactatt tcagcttcta aactttattt
31861 gcaatgcctt cccatggcag actccttctg tcattttgcc tctgttcgaa aactttttcc
31921 ttaatttcat tcttagttaa taatatctga aattattttg ttgtttaact taattattaa
31981 ttttatgtat gttctaccta gatataatct tctagaggat tgttttattc tctgacttat
32041 ttaacttaaa tgcccactac ctttaaaaat tatgacattt atttaacaga tatttgctga
32101 acaaatgttt gaaaatacat gggaaagaat gcttgaaaac acttgaaatt gcttgtgtaa
32161 agaaacagtt ttatcagtta ggatttaatc aatgtcagaa gcaatgatat aggaaaaatc
32221 gaggaataag acagttatgg ataaggagaa atcaacaaac tcttaaaaga tattgcctca
32281 aaagcataag aggaaataag ggtttataca tgacttttag aacactgcct gggtttttgg
32341 ataaatgggg aagttgttgg aaaacaggag ggatcctaga tattccttag tctgaggagg
32401 agcaattaag attcacttgt ttagaggctg ggagtggtgg ctcacgcctg taatcccaga
32461 attttgggag gccaaggcag gcagatcacc tgaggtcaag agttcaagac caacctggcc
32521 aacatggtga aatcccatct ctacaaaaat acaaaaatta gacaggcatg atggcaagtg
32581 cctgtaatcc cagctacttg ggaggctgag gaaggagaat tgcttgaacc tggaaggcag
32641 gagttgcagt gagccgagat cataccactg cactccagcc tgggtgacag aacaagactc
32701 tgtctcaaaa aaaaaaaaga gagattcaaa agattcactt gtttaggcct tagcgggctt
32761 agacaccagt ctctgacaca ttcttaaagg tcaggctcta caaatggaac ccaaccagac
32821 tctcagatat ggccaaagat ctatacacac ccatctcaca gatcccctat cttaaagaga
32881 ccctaatttg ggttcacctc agtctctata atctgtacca gcataccaat aaaaatcttt
32941 ctcacccatc cttagattga gagaagtcac ttattattat gtgagtaact ggaagatact
33001 gataagttga caaatctttt tctttccttt cttattcaac ttttatttta acttccaaag
33061 aacaagtgca atatgtgcag ctttgttgcg caggtcaaca tgtatctttc tggtctttta
33121 gccgcctaac actttgagca gatataagcc ttacacagga ttatgaagtc tgaaaggatt
33181 ccaccaatat tattataatt cctatcaacc tgataagtta ggggaaggta gagctctcct
33241 ccaataagcc agatttccag agtttctgac gtcataatct accaaggtca tggatcgagt
33301 tcagagaaaa aacaaaagca aaaccaaacc taccaaaaaa taaaaatccc aaagaaaaaa
33361 taaagaaaaa aacagcatga atacttcctg ccatgttaag tggccaatat gtcagaaaca
33421 gcactgagtt acagataaag atgtctaaac tacagtgaca tcccagctgt cacagtgtgt
33481 ggactattag tcaataaaac agtccctgcc tcttaagagt tgttttccat gcaaatacat
33541 gtcttatgtc ttagaataag attccctaag aagtgaacct agcatttata caagataatt
33601 aattctaatc catagtatct ggtaaagagc attctaccat catctttacc gagcatagaa
33661 gagctacacc aaaaccctgg gtcatcagcc agcacataca cttatccagt gataaataca
33721 catcatcggg tgcctacata catacctgaa tataaaaaaa atacttttgc tgagatgaaa
33781 caggcgtgat ttatttcaaa taggtacgga taagtagata ttgaagtaag gattcagtct
33841 tatattatat tacataacat taatctattc ctgcactgaa actgttgctt tataggattt
33901 ttcactacac taatgagaac ttaagagata atggcctaaa accacagaga gtatattcaa
33961 gaataagtat agcacttctt atttggaaac caatgcttac taaatgagac taagacgtgt
34021 cccatcaaaa atcctggacc tatgcctaaa acacatttca caatccctga acttttcaaa
34081 aattggtaca tgctttaact ttaaactaca ggcctcactg gagctacaga caagaaggtg
34141 aaaaacggct gacaaaagaa gtcctggtat cttctatggt gggagaagaa aactagctaa
34201 agggaagaat aaattagaga aaaattggaa tgactgaatc ggaacaaggc aaaggctata
34261 aaaaaaatta agcagcagta tcctcttggg ggccccttcc ccacactatc tcaatgcaaa
34321 tatctgtctg aaacggttcc tggctaaact ccacccatgg gttggccagc cttgccttga
34381 ccaatagcct tgacaaggca aacttgacca atagtcttag agtatccagt gaggccaggg
34441 gccggcggct ggctagggat gaagaataaa aggaagcacc cttcagcagt tccacacact
34501 cgcttctgga acgtctgagg ttatcaataa gctcctagtc cagacgccat gggtcatttc
34561 acagaggagg acaaggctac tatcacaagc ctgtggggca aggtgaatgt ggaagatgct
34621 ggaggagaaa ccctgggaag gtaggctctg gtgaccagga caagggaggg aaggaaggac
34681 cctgtgcctg gcaaaagtcc aggtcgcttc tcaggatttg tggcaccttc tgactgtcaa
34741 actgttcttg tcaatctcac aggctcctgg ttgtctaccc atggacccag aggttctttg
34801 acagctttgg caacctgtcc tctgcctctg ccatcatggg caaccccaaa gtcaaggcac
34861 atggcaagaa ggtgctgact tccttgggag atgccataaa gcacctggat gatctcaagg
34921 gcacctttgc ccagctgagt gaactgcact gtgacaagct gcatgtggat cctgagaact
34981 tcaaggtgag tccaggagat gtttcagcac tgttgccttt agtctcgagg caacttagac
35041 aactgagtat tgatctgagc acagcagggt gtgagctgtt tgaagatact ggggttggga
35101 gtgaagaaac tgcagaggac taactgggct gagacccagt ggcaatgttt tagggcctaa
35161 ggagtgcctc tgaaaatcta gatggacaac tttgactttg agaaaagaga ggtggaaatg
35221 aggaaaatga cttttcttta ttagatttcg gtagaaagaa ctttcacctt tcccctattt
35281 ttgttattcg ttttaaaaca tctatctgga ggcaggacaa gtatggtcgt taaaaagatg
35341 caggcagaag gcatatattg gctcagtcaa agtggggaac tttggtggcc aaacatacat
35401 tgctaaggct attcctatat cagctggaca catataaaat gctgctaatg cttcattaca
35461 aacttatatc ctttaattcc agatgggggc aaagtatgtc caggggtgag gaacaattga
35521 aacatttggg ctggagtaga ttttgaaagt cagctctgtg tgtgtgtgtg tgtgtgtgcg
35581 cgcgtgtgtt tgtgtgtgtg tgagagcgtg tgtttctttt aacgttttca gcctacagca
35641 tacagggttc atggtggcaa gaagataaca agatttaaat tatggccagt gactagtgct
35701 gcaagaagaa caactacctg catttaatgg gaaagcaaaa tctcaggctt tgagggaagt
35761 taacataggc ttgattctgg gtggaagctt ggtgtgtagt tatctggagg ccaggctgga
35821 gctctcagct cactatgggt tcatctttat tgtctccttt catctcaaca gctcctggga
35881 aatgtgctgg tgaccgtttt ggcaatccat ttcggcaaag aattcacccc tgaggtgcag
35941 gcttcctggc agaagatggt gactggagtg gccagtgccc tgtcctccag ataccactga
36001 gctcactgcc catgatgcag agctttcaag gataggcttt attctgcaag caatacaaat
36061 aataaatcta ttctgctaag agatcacaca tggttgtctt cagttctttt ttttatgtct
36121 ttttaaatat atgagccaca aagggtttta tgttgaggga tgtgtttatg tgtatttata
36181 catggctatg tgtgtttgtg tcatgtgcac actccacact tttttgttta cgttagatgt
36241 gggttttgat gagcaaataa aagaactagg caataaagaa acttatacat gggagcgtct
36301 gcaagtggga gtaaaaggtg caggagaaat ctggttggaa gaaagacctc tataggacag
36361 gactcctcag aaacagatgt tttggaagag atggggaaag gttcagtgaa gggggctgaa
36421 cccccttccc tggattgcag cacagcagcg aggaaggggc tcaacgaaga aaaagtgttc
36481 caagctttag gaagtcaagg tttaggcagg gatagccatt ctattttatt aggggcaata
36541 ctatttccaa cggcatctgg cttttctcag cccttgtgag gctctacggg gaggttgagg
36601 tgttagagat cagagcagga aacaggtttt tctttccacg gtaactacaa tgaagtgatc
36661 cttactttac taaggaactt tttcatttta agtgttgacg catgcctaaa gaggtgaaat
36721 taatcccata cccttaagtc tacagactgg tcacagcatt tcaaggagga gacctcattg
36781 taagcttcta gggaggtggg gacctaggtg aaggaaatga gccagcagaa gctcacaagt
36841 cagcatcagc gtgtcatgtc tcagcagcag aacagcacgg tcagatgaaa atatagtgtg
36901 aagaatttgt ataacattaa ttgagaaggc agattcactg gagttcttat ataattgaaa
36961 gttaatgcac gttaataagc aagagtttag tttaatgtga tggtgttatg aacttaacgc
37021 ttgtgtctcc agaaaattca catgctgaat ccccaactcc caattggctc catttgtggg
37081 ggaggctttg gaaaagtaat caggtttaga ggagctcatg agagcagatc cccatcatag
37141 aattattttc ctcatcagaa gcagagagat tagccatttc tcttccttct ggtgaggaca
37201 cagtgggaag tcagccacct gcaacccagg aagagagccc tgaccaggaa ccagcagaaa
37261 agtgagaaaa aatcctgttg ttgaagtcac ccagtctatg ctattttgtt atagcacctt
37321 gcactaagta aggcagatga agaaagagaa aaaaataagc ttcggtgttc agtggattag
37381 aaaccatgtt tatctcaggt ttacaaatct ccacttgtcc tctgtgtttc agaataaaat
37441 accaactcta ctactctcat ctgtaagatg caaatagtaa gcctgatccc ttctgtctaa
37501 cttcgaattc tattttttct tcaacgtact ttaggcttgt aatgtgttta tatacagtga
37561 aatgtcaagt tctttcttta tatttctttc tttctttttt ttcctcagcc tcagagtttt
37621 ccacatgccc ttcctacctt caggaacttc tttctccaaa cgtcttctgc ctggcctcca
37681 ttcaaatcat aaaggaccca cttcaaatgc catcactcac taccatttca caattcgcac
37741 tttctttctt tgtccttttt ttttttagta aaacaagttt ataaaaaatt gaaggaataa
37801 atgaatggct acttcatagg cagagtagac acaagggcta ctggttgccg atttttattg
37861 ttatttttca atagtatgct aaacaagggg tagattattt atgctgccca tttttagacc
37921 ataaaagata acttcctgat gttgccatgg catttttttt ccttttaatt ttatttcatt
37981 tcattttaat ttcgaaggta catgtgcagg atgtgcaggc ttgttacatg ggtaaatgtg
38041 tgtctttctg gccttttagc catctgtatc aatgagcaga tataagcttt acacaggatc
38101 atgaaggatg aaagaatttc accaatatta taataatttc aatcaacctg atagcttagg
38161 ggataaacta atttgaagat acagcttgcc tccgataagc cagaattcca gagcttctgg
38221 cattataatc tagcaaggtt agagatcatg gatcactttc agagaaaaac aaaaacaaac
38281 taaccaaaag caaaacagaa ccaaaaaacc tccataaata cttcctaccc agttaatggt
38341 ccaatatgtc agaaacagca ctgtgttaga aataaagctg tctaaagtac actaatattc
38401 gagttataat agtgtgtgga ctattagtca ataaaaacaa cccttgcctc tttagagttg
38461 ttttccatgt acacgcacat cttatgtctt agagtaagat tccctgagaa gtgaacctag
38521 catttataca agataattaa ttctaatcca cagtacctgc caaagaacat tctaccatca
38581 tctttactga gcatagaaga gctacgccaa aaccctgggt catcagccag cacacacact
38641 tatccagtgg taaatacaca tcatctggtg tatacataca tacctgaata tggaatcaaa
38701 tatttttcta agatgaaaca gtcatgattt atttcaaata ggtacggata agtagatatt
38761 gaggtaagca ttaggtctta tattatgtaa cactaatcta ttactgcgct gaaactgtgg
38821 tctttatgaa aattgttttc actacactat tgagaaatta agagataatg gcaaaagtca
38881 caaagagtat attcaaaaag aagtatagca ctttttcctt agaaaccact gctaactgaa
38941 agagactaag atttgtcccg tcaaaaatcc tggacctatg cctaaaacac atttcacaat
39001 ccctgaactt ttcaaaaatt ggtacatgct ttagctttaa actacaggcc tcactggagc
39061 tacagacaag aaggtaaaaa acggctgaca aaagaagtcc tggtatcctc tatgatggga
39121 gaaggaaact agctaaaggg aagaataaat tagagaaaaa ctggaatgac tgaatcggaa
39181 caaggcaaag gctataaaaa aaattaagca gcagtatcct cttgggggcc ccttccccac
39241 actatctcaa tgcaaatatc tgtctgaaac ggtccctggc taaactccac ccatgggttg
39301 gccagccttg ccttgaccaa tagccttgac aaggcaaact tgaccaatag tcttagagta
39361 tccagtgagg ccaggggccg gcggctggct agggatgaag aataaaagga agcacccttc
39421 agcagttcca cacactcgct tctggaacgt ctgagattat caataagctc ctagtccaga
39481 cgccatgggt catttcacag aggaggacaa ggctactatc acaagcctgt ggggcaaggt
39541 gaatgtggaa gatgctggag gagaaaccct gggaaggtag gctctggtga ccaggacaag
39601 ggagggaagg aaggaccctg tgcctggcaa aagtccaggt cgcttctcag gatttgtggc
39661 accttctgac tgtcaaactg ttcttgtcaa tctcacaggc tcctggttgt ctacccatgg
39721 acccagaggt tctttgacag ctttggcaac ctgtcctctg cctctgccat catgggcaac
39781 cccaaagtca aggcacatgg caagaaggtg ctgacttcct tgggagatgc cataaagcac
39841 ctggatgatc tcaagggcac ctttgcccag ctgagtgaac tgcactgtga caagctgcat
39901 gtggatcctg agaacttcaa ggtgagtcca ggagatgttt cagcactgtt gcctttagtc
39961 tcgaggcaac ttagacaact gagtattgat ctgagcacag cagggtgtga gctgtttgaa
40021 gatactgggg ttgggagtga agaaactgca gaggactaac tgggctgaga cccagtggca
40081 atgttttagg gcctaaggag tgcctctgaa aatctagatg gacaactttg actttgagaa
40141 aagagaggtg gaaatgagga aaatgacttt tctttattag atttcggtag aaagaacttt
40201 cacctttccc ctatttttgt tattcgtttt aaaacatcta tctggaggca ggacaagtat
40261 ggtcgttaaa aagatgcagg cagaaggcat atattggctc agtcaaagtg gggaactttg
40321 gtggccaaac atacattgct aaggctattc ctatatcagc tggacacata taaaatgctg
40381 ctaatgcttc attacaaact tatatccttt aattccagat gggggcaaag tatgtccagg
40441 ggtgaggaac aattgaaaca tttgggctgg agtagatttt gaaagtcagc tctgtgtgtg
40501 tgtgtgtgtg tgtgtgtgtc agcgtgtgtt tcttttaacg tcttcagcct acaacataca
40561 gggttcatgg tgggaagaag atagcaagat ttaaattatg gccagtgact agtgcttgaa
40621 ggggaacaac tacctgcatt taatgggaag gcaaaatctc aggctttgag ggaagttaac
40681 ataggcttga ttctgggtgg aagctgggtg tgtagttatc tggaggccag gctggagctc
40741 tcagctcact atgggttcat ctttattgtc tcctttcatc tcaacagctc ctgggaaatg
40801 tgctggtgac cgttttggca atccatttcg gcaaagaatt cacccctgag gtgcaggctt
40861 cctggcagaa gatggtgact gcagtggcca gtgccctgtc ctccagatac cactgagcct
40921 cttgcccatg attcagagct ttcaaggata ggctttattc tgcaagcaat acaaataata
40981 aatctattct gctgagagat cacacatgat tttcttcagc tctttttttt acatcttttt
41041 aaatatatga gccacaaagg gtttatattg agggaagtgt gtatgtgtat ttctgcatgc
41101 ctgtttgtgt ttgtggtgtg tgcatgctcc tcatttattt ttatatgaga tgtgcatttt
41161 gatgagcaaa taaaagcagt aaagacactt gtacacggga gttctgcaag tgggagtaaa
41221 tggtgttgga gaaatccggt gggaagaaag acctctatag gacaggactt ctcagaaaca
41281 gatgttttgg aagagatggg aaaaggttca gtgaagacct gggggctgga ttgattgcag
41341 ctgagtagca aggatggttc ttaatgaagg gaaagtgttc caagctttag gaattcaagg
41401 tttagtcagg tgtagcaatt ctattttatt aggaggaata ctatttctaa tggcacttag
41461 cttttcacag cccttgtgga tgcctaagaa agtgaaatta atcccatgcc ctcaagtgtg
41521 cagattggtc acagcatttc aagggagaga cctcattgta agactctggg ggaggtgggg
41581 acttaggtgt aagaaatgaa tcagcagagg ctcacaagtc agcatgagca tgttatgtct
41641 gagaaacaga ccagcactgt gagatcaaaa tgtagtggga agaatttgta caacattaat
41701 tggaaggttt acttaatgga atttttgtat agttggatgt tagtgcatct ctataagtaa
41761 gagtttaata tgatggtgtt acggacctgg tgtttgtgtc tcctcaaaat tcacatgctg
41821 aatccccaac tcccaactga ccttatctgt gggggaggct tttgaaaagt aattaggttt
41881 agctgagctc ataagagcag atccccatca taaaattatt ttccttatca gaagcagaga
41941 gacaagccat ttctctttcc tcccggtgag gacacagtga gaagtccgcc atctgcaatc
42001 caggaagaga accctgacca cgagtcagcc ttcagaaatg tgagaaaaaa ctctgttgtt
42061 gaagccaccc agtcttttgt attttgttat agcaccttac actgagtaag gcagatgaag
42121 aaggagaaaa aaataagctt gggttttgag tgaactacag accatgttat ctcaggtttg
42181 caaagctccc ctcgtcccct atgtttcagc ataaaatacc tactctacta ctctcatcta
42241 taagacccaa ataataagcc tgcgcccttc tctctaactt tgatttctcc tatttttact
42301 tcaacatgct ttactctagc cttgtaatgt ctttacatac agtgaaatgt aaagttcttt
42361 attctttttt tctttctttc ttttttctcc tcagcctcag aatttggcac atgcccttcc
42421 ttctttcagg aacttctcca acatctctgc ctggctccat catatcataa aggtcccact
42481 tcaaatgcag tcactaccgt ttcaggatat gcactttctt tcttttttgt tttttgtttt
42541 ttttaagtca aagcaaattt cttgagagag taaagaaata aacgaatgac tactgcatag
42601 gcagagcagc cccgagggcc gctggttgtt ccttttatgg ttatttcttg atgatatgtt
42661 aaacaagttt tggattattt atgccttctc tttttaggcc atatagggta actttctgac
42721 attgccatgg catgtttctt ttaatttaat ttactgttac cttaaattca ggggtacacg
42781 tacaggatat gcaggtttgt tttataggta aaagtgtgcc atggttttaa tgggtttttt
42841 ttttcttgta aagttgttta agtttcttgt ttactctgga tattggcctt tgtcagaaga
42901 atagattgga aaatcttttt cccattctgt agattgtctt tcgctctgat ggtagtttct
42961 tttgctgagc aggagctctt tagtttaatt agattccatt ggtcaatttt tgcttttgct
43021 gcaattgctt ttcacgcttt catcatgaaa tctgtgcccg tgtttatatc atgaatagta
43081 ttgccttgat ttttttctag gctttttata gtttggggtt tttcatttaa gtctctaatc
43141 catccggagt taattttgga taaggtataa ggaaggagtc cagtttcatt tttcagcata
43201 tggctagcca gttctccccc atcatttatt aaattgaaaa tcctttcccc attgcttgct
43261 tttgtcaggt ttctaaaaga cagatggttg taggtacaat atgcagtttc ttcaagtcat
43321 ataataccat ctgaaatctc ttattaattc atttctttta gtatgtatgc tggtctcctc
43381 tgctcactat agtgagggca ccattagcca gagaatctgt ctgtctagtt catgtaagat
43441 tctcagaatt aagaaaaatg gatggcatat gaatgaaact tcatggatga catatggaat
43501 ctaatgtgta tttgttgaat taatgcataa gatgcaacaa gggaaaggtt gacaactgca
43561 gtgataacct ggtattgatg atataagagt ctatagatca cagtagaagc aataatcatg
43621 gaaaacaatt ggaaatgggg aacagccaca aacaagaaag aatcaatact accaggaaag
43681 tgactgcagg tcacttttcc tggagcgggt gagagaaaag tggaagttgc agtaactgcc
43741 gaattcctgg ttggctgatg gaaagatggg gcaactgttc actggtacgc agggttttag
43801 atgtatgtac ctaaggatat gaggtatggc aatgaacaga aattcttttg ggaatgagtt
43861 ttagggccat taaaggacat gacctgaagt ttcctctgag gccagtcccc acaactcaat
43921 ataaatgtgt ttcctgcata tagtcaaagt tgccacttct ttttcttcat atcatcgatc
43981 tctgctctta aagataatct tggttttgcc tcaaactgtt tgtcactaca aactttcccc
44041 atgttcctaa gtaaaacagg taactgcctc tcaactatat caagtagact aaaatattgt
44101 gtctctaata tcagaaattc agctttaata tattgggttt aactctttga aatttagagt
44161 ctccttgaaa tacacatggg ggtgatttcc taaactttat ttcttgtaag gatttatctc
44221 aggggtaaca cacaaaccag catcctgaac ctctaagtat gaggacagta agccttaaga
44281 atataaaata aactgttctt ctctctgccg gtggaagtgt gccctgtcta ttcctgaaat
44341 tgcttgtttg agacgcatga gacgtgcagc acatgagaca cgtgcagcag cctgtggaat
44401 attgtcagtg aagaatgtct ttgcctgatt agatataaag acaagttaaa cacagcatta
44461 gactatagat caagcctgtg ccagacacaa atgacctaat gcccagcacg ggccacggaa
44521 tctcctatcc tcttgcttga acagagcagc acacttctcc cccaacacta ttagatgttc
44581 tggcataatt ttgtagatat gtaggatttg acatggacta ttgttcaatg attcagagga
44641 aatctccttt gttcagataa gtacactgac tactaaatgg attaaaaaac acagtaataa
44701 aacccagttt tccccttact tccctagttt gtttcttatt ctgctttctt ccaagttgat
44761 gctggataga ggtgtttatt tctattctaa aaagtgatga aattggccgg gcgcggtggc
44821 tcacacctgt aatcccagca ctttgggagg ctgaggtggg cggatcacga ggtcaggaga
44881 tcaagaccat cctggctaac atggtgaaac cccatctcta ctaaaaatac aaaaaattag
44941 ccagagacgg tggcgggtgc ctgtagtccc agctactcgg gaggctgagg caggagaatg
45001 gcgtgaacct gggaggcaga gctgcagtga gcagagatcg cgccactgca cactccagcc
45061 tgggtgacaa agcgagactc catctcaaaa aaaaaaaaaa aaaaaaaaag aaagaaagaa
45121 agaaaaaaaa agtgatgaaa ttgtgtattc aatgtagtct caagagaatt gaaaaccaag
45181 aaaggctgtg gcttcttcca cataaagcct ggatgaataa caggataaca cgttgttaca
45241 ttgtcacaac tcctgatcca ggaattgatg gctaagatat tcgtaattct tatccttttc
45301 agttgtaact tattcctatt tgtcagcatt caggttatta gcggctgctg gcgaagtcct
45361 tgagaaataa actgcacact ggatggtggg ggtagtgtag gaaaatggag gggaaggaag
45421 taaagtttca aattaagcct gaacagcaaa gttcccctga gaaggccacc tggattctat
45481 cagaaactcg aatgtccatc ttgcaaaact tccttgccca aaccccaccc ctggagtcac
45541 aacccaccct tgaccaatag attcatttca ctgagggagg caaagggctg gtcaatagat
45601 tcatttcact gggagaggca aagggctggg ggccagagag gagaagtaaa aagccacaca
45661 tgaagcagca atgcaggcat gcttctggct catctgtgat caccaggaaa ctcccagatc
45721 tgacactgta gtgcatttca ctgctgacaa gaaggctgct gccaccagcc tgtgaagcaa
45781 ggttaaggtg agaaggctgg aggtgagatt ctgggcaggt aggtactgga agccgggaca
45841 aggtgcagaa aggcagaaag tgtttctgaa agagggatta gcccgttgtc ttacatagtc
45901 tgactttgca cctgctctgt gattatgact atcccacagt ctcctggttg tctacccatg
45961 gacctagagg tactttgaaa gttttggata tctgggctct gactgtgcaa taatgggcaa
46021 ccccaaagtc aaggcacatg gcaagaaggt gctgatctcc ttcggaaaag ctgttatgct
46081 cacggatgac ctcaaaggca cctttgctac actgagtgac ctgcactgta acaagctgca
46141 cgtggaccct gagaacttcc tggtgagtag taagtacact cacgctttct tctttaccct
46201 tagatatttg cactatgggt acttttgaaa gcagaggtgg ctttctcttg tgttatgagt
46261 cagctatggg atatgatatt tcagcagtgg gattttgaga gttatgttgc tgtaaataac
46321 ataactaaaa tttggtagag caaggactat gaataatgga aggccactta ccatttgata
46381 gctctgaaaa acacatctta taaaaaattc tggccaaaat caaactgagt gttttggatg
46441 agggaacaga agttgagata gagaaaataa catctttcct ttggtcagcg aaattttcta
46501 taaaaattaa tagtcacttt tctgcatagt cctggaggtt agaaaaagat caactgaaca
46561 aagtagtggg aagctgttaa aagaggattg tttccctccg aatgatgatg gtatactttt
46621 gtacgcatgg tacaggattc tttgttatga gtgtttggga aaattgtatg tatgtatgta
46681 tgtatgtgat gactggggac ttatcctatc cattactgtt ccttgaagta ctattatcct
46741 actttttaaa aggacgaagt ctctaaaaaa aaaatgaaac aatcacaata tgttggggta
46801 gtgagttggc atagcaagta agagaaggat aggacacaat gggaggtgca gggctgccag
46861 tcatattgaa gctgatatct agcccataat ggtgagagtt gctcaaactc tggtcaaaaa
46921 ggatgtaagt gttatatcta tttactgcaa gtccagcttg aggccttcta ttcactatgt
46981 accattttct tttttatctt cactccctcc ccagctctta ggcaacgtga tattgattgt
47041 tttggcaacc cacttcagcg aggattttac cctacagata caggcttctt ggcagtaact
47101 aacaaatgct gtggttaatg ctgtagccca caagaccact gagttccctg tccactatgt
47161 ttgtacctat gtcccaaaat ctcatctcct ttagatgggg gaggttgggg agaagagcag
47221 tatcctgcct gctgattcag ttcctgcatg ataaaaatag aataaagaaa tatgctctct
47281 aagaaatatc attgtactct ttttctgtct ttatatttta ccctgattca gccaaaagga
47341 cgcactattt ctgatggaaa tgagaatgtt ggagaatggg agtttaagga cagagaagat
47401 actttcttgc aatcctgcaa gaaaagagag aactcgtggg tggatttagt ggggtagtta
47461 ctcctaggaa ggggaaatcg tctctagaat aagacaatgt ttttacagaa agggaggtca
47521 atggaggtac tctttggagg tgtaagagga ttgttggtag tgtgtagagg tatgttagga
47581 ctcaaattag aagttctgta taggctatta tttgtatgaa actcaggata tagctcattt
47641 ggtgactgca gttcacttct acttatttta aacaacatat tttttatgat ttataatgaa
47701 gtggggatgg ggcttcctag agaccaatca agggccaaac cttgaacttt ctcttaacgt
47761 cttcaatggt attaatagag aattatctct aaggcatgtg aactggctgt cttggttttc
47821 atctgtactt catctgctac ctctgtgacc tgaaacatat ttataattcc attaagctgt
47881 gcatatgata gatttatcat atgtattttc cttaaaggat ttttgtaaga actaattgaa
47941 ttgatacctg taaagtcttt atcacactac ccaataaata ataaatctct ttgttcagct
48001 ctctgtttct ataaatatgt acaagtttta ttgtttttag tggtagtgat tttattctct
48061 ttctatatat atacacacac atgtgtgcat tcataaatat atacaatttt tatgaataaa
48121 aaattattag caatcaatat tgaaaaccac tgatttttgt ttatgtgagc aaacagcaga
48181 ttaaaaggct gagatttagg aaacagcacg ttaagtcaag ttgatagagg agaatatgga
48241 catttaaaag aggcaggatg atataaaatt agggaaactg gatgcagaga ccagatgaag
48301 taagaaaaat agctatcgtt ttgagcaaaa atcactgaag tttcttgcat atgagagtga
48361 cataataaat agggaaacgt agaaaattga ttcacatgta tatatatata tagaactgat
48421 tagacaaagt ctaacttggg tatagtcaga ggagcttgct gtaattatat tgaggtgatg
48481 gataaagaac tgaagttgat ggaaacaatg aagttaagaa aaaaaatcga gtaagagacc
48541 attgtggcag tgattgcaca gaactggaaa acattgtgaa acagagagtc agagatgaca
48601 gctaaaatcc ctgtctgtga atgaaaagaa ggaaatttat tgacagaaca gcaaatgcct
48661 acaagccccc tgtttggatc tggcaatgaa cgtagccatt ctgtggcaat cacttcaaac
48721 tcctgtaccc aagaccctta ggaagtatgt agcaccctca aacctaaaac ctcaaagaaa
48781 gaggttttag aagatataat accctttctt ctccagtttc attaatccca aaacctcttt
48841 ctcaaagtat ttcctctatg tgtccacccc aaagagctca cctcaccata tctcttgagt
48901 gggagcacat agataggcgg tgctaccatc taacagcttc tgaaattcct ttgtcatatt
48961 tttgagtccc cactaataac ccacaaagca gaataaatac cagttgctca tgtacaataa
49021 tcactcaact gctgtcttgt agcatacatt aattaagcac attctttgaa taattactgt
49081 gtccaaacaa tcacacttta aaatctcaca cttgtgctat cccttgccct tctgaatgtc
49141 actctgtatt ttaaatgaag agatgagggt tgaatttcct gtgttactta ttgttcattt
49201 ctcgatgagg agttttcaca ttcaccttta ctggaaaaca cataagtaca catcttacag
49261 gaaaaatata ccaaactgac atgtagcatg aatgcttgtg catgtagtca tataaaatct
49321 tgtagcaatg taaacattct ctgatataca catacagatg tgtctatatg tctacacaat
49381 ttcttatgct ccatgaacaa acattccatg cacacataag aacacacact gttacagatg
49441 catacttgag tgcattgaca aaattacccc agtcaatcta gagaatttgg atttctgcat
49501 ttgactctgt tagctttgta catgctgttc atttactctg ggtgatgtct ttccctcatt
49561 ttgccttgtc tatcttgtac tcatacttta agtcctaact tatatgttat ctcaactaag
49621 aagctatttt tttttaattt taactgggct taaagccctg tctataaact ctgctacaat
49681 tatgggctct ttcttataat atttagtgtt tttcctacta atgtacttaa tctgctcatt
49741 gtatattcct accactaaat tttaacctct tttatggtag agacattgtc ttgtaaactc
49801 ttatttccct agtatttgga gatgaaaaaa aagattaaat tatccaaaat tagatctctc
49861 ttttctacat tatgagtatt acactatcca tagggaagtt tgtttgagac ctaaactgag
49921 gaacctttgg ttctaaaatg actatgtgat atcttagtat ttataggtca tgaggttcct
49981 tcctctgcct ctgctatagt ttgattagtc agcaagcatg tgtcatgcat ttattcacat
50041 cagaatttca tacactaata agacatagta tcagaagtca gtttattagt tatatcagtt
50101 agggtccatc aaggaaagga caaaccatta tcagttactc aacctagaat taaatacagc
50161 tcttaatagt taattatcct tgtattggaa gagctaaaat atcaaataaa ggacagtgca
50221 gaaatctaga tgttagtaac atcagaaaac ctcttccgcc attaggccta gaagggcaga
50281 aggagaaaat gtttatacca ccagagtcca gaaccagagc ccataaccag aggtccactg
50341 gattcagtga gctagtgggt gctccttgga gagagccaga actgtctaat gggggcatca
50401 aagtatcagc cataaaaaac cataaaaaag actgtctgct gtaggagatc cgttcagaga
50461 gagagagaga ccagaaataa tcttgcttat gctttccctc agccagtgtt taccattgca
50521 gaatgtacat gcgactgaaa gggtgaggaa acctgggaaa tgtcagttcc tcaaatacag
50581 agaacactga gggaaggatg agaaataaat gtgaaagcag acatgaatgg taattgacag
50641 aaggaaacta ggatgtgtcc agtaaatgaa taattacagt gtgcagtgat tattgcaatg
50701 attaatgtat tgataagata atatgaaaac acagaattca aacagcagtg aactgagatt
50761 agaattgtgg agagcactgg catttaagaa tgtcacactt agaatgtgtc tctaggcatt
50821 gttctgtgca tatatcatct caatattcat tatctgaaaa ttatgaatta ggtacaaagc
50881 tcaaataatt tattttttca ggttagcaag aacttttttt tttttttttt ctgagatgga
50941 gcattgctat ggttgcccag gctggagtgc aatggcatga tccaggctca ctgcaacatc
51001 tgcctcccag gttcaagcga ttctcctgcc tcagcctccc aagtagctgg cattacaggc
51061 atgtgccacc accatgcctg gctaattttc tatttttagt agataggggg tttcaccatg
51121 ttggtcaggc tgatctcgaa ctcctaacat caggtgatcc accctcctcg gcctctgaat
51181 gtactgggat cacaggcgtg agccaccaca cccagccaag aatgtgaatt ttgtagaagg
51241 atataaccca tatttctctg accctagagt ccttagtata cctcccatac catgtggctc
51301 atcctcctta catacatttc ccatctttca ccctaccttt tcctttttgt ttcagctttt
51361 cactgtgtgt caaaatctag aaccttatct cctacctgct ctgaaaccaa cagcaagttg
51421 acttccattc taacccacat tggcattaca ctaattaaaa tcgatactga gttctaaaat
51481 catctgggat tttggggact atgtcttact tcatacttcc ttgagatttc acattaaatg
51541 ttggtgttca ttaaaggtcc ttcatttaac tttgtattca tcacactctt ggattcacag
51601 ttatatctaa actcttatat atagcctgta taatcccaat tcccaagtct gatttctaac
51661 ctctgacctc caacctcagt gccaaaccca tatatcaaac aatgtactgg gcttatttat
51721 atagatgtcc tataggcacc tcagactcag catgggtatt tcacttgtta tactaaaact
51781 gtttctcttc cagtgttttc cattttagtc attagatagc tacttgccca ttcaccaagg
51841 tcacagatta aaatcatttc cctacctcta atcaacagtt caattctgct tcaatttgtc
51901 cctatctatt aatcaccact cttactgccc agtcaggtcc tcattgtttc ctgaacaaga
51961 gtagatgcta ttctttccac tttaagacct tatcctggct ggatgcggtg gctcaggctt
52021 gtaaacccag cactttggga ggccgaggca ggcagatcac ttgaggtcag gagttcaaga
52081 ccagcctgac caacatggtg aaaccccatc tctactaaaa atacaaaatc agccgggcgt
52141 gtggtgcatg cctgcagtcc cagctattca ggtggctgag gcaggagaat tgcttgaacc
52201 caggaggcgg aggttgcggt gagcctagat tgcaccattg cactctagct tgggcaatag
52261 ggatgaaact ccatctcaga agagaaaaga aaaaaagacc ttattctgtt acacaaatcc
52321 tctcaatgca atccatatag aataaacatg taaccagatc tcccaatgtg taaaatcatt
52381 tcaggtagaa cagaattaaa gtgaaaagcc aagtctttgg aattaacaga caaagttcaa
52441 ataacagtcc tcatggcctt aagaatttac ctaacatttt ttttagaatc aattttctta
52501 tatatgaatt ggaaacataa ttcctccctc acaaacacat tctaagattt taaggagata
52561 ttgatgaagt acatcatctg tcatttttaa cagttagtgg tagtgattca cacagcacat
52621 tatgatctgt tcttgtatgt tctgttccat tctgtattct tgacctggtt gtattctttc
52681 tgagctccag atccacatat ctaagtacat ctttttgcat tttacaagag tgcatacaat
52741 acaatgtatc caagactgta tttctgattt tatcgtacca ctaaactcac aaatgtggcc
52801 ctattcttgt gttcacgact gacatcaccg tcatggtcca agtctgataa tagaaatggc
52861 attgtcactt tcttccctac tgcaacagaa gcccagctat ttgtctccca ttttctctac
52921 ttctaaaata catttcttca ctaagtgaga ataatctttt aaagacacaa atcaaaccat
52981 gccaccacct ttcttgaatt attcaatatc tttcgttggc ttccaggtta cagaaaaata
53041 acttgtaaca aagtttaaag gtcattcatg gctcctctct accctatttt ataacatttc
53101 cccttgtgat cagaatctca ggcacatcat ccatctttct atatacaaat aaagtcatat
53161 agtttgaact cacctctggt tacttttaat caaccaaatg ctgtaaaatg catttgtatc
53221 gctacgtgtt aagcagtagt tgattctttt catttcttgt taatattcta ttctttgact
53281 ataccgtaat ttatcaattc tactgttggt aagcatttaa gtggctaccg gtttgaggtt
53341 tttatgatta ttgctgtcat aagcatttct atacatgtct ttggatacac acatgcatgt
53401 gtttctgaat atctaaaaat gtaattgcta ggtaatagac ttatcaagca tccagcattt
53461 gtggatacta ttaaaggttt tccaaagggg ttatactatt gtacagtgtc accaacagag
53521 tttgagtttc tattgatcca tatcaccacc aaaatttgaa ctgtcagtct tatctcttct
53581 cttgtctctt ttttcctctt ttttttcctt cccttcccct ctcttcgttt cttttctctc
53641 ctcttctctt ctttcctctc ttcccttccc tttctctttc tcttccctat cccttctcct
53701 ctcctctccc ctcctttttt ctcctctcct ctccattatt tatttttcct tcttctcctc
53761 catcccttcc atcctctctc ttcccctctt ccttccttcc tttctccatt tcttcctcct
53821 ctttccctca atccttcctt ttggatatgc tcatgggtgt gtatttgtct gccattgtgg
53881 cattatttga attcagaaaa gagtgaaaaa ctactgggat cttcattctg ggtctaattc
53941 cacatttttt tttaagaaca cactctgtaa aaatgttctg tactagcata ttcccaggaa
54001 cttcgttaaa tttaatctgg ctgaatatgg taaatctact ttgcactttg cattctttct
54061 ttagtcatac cataatttta aacattcaaa atatttgtat ataatatttg attttatctg
54121 tcattaaaat gttaacctta aaattcatgt ttccagaacc tatttcaata actggtaaat
54181 aaacactatt cattttttaa atattctttt aatggatatt tatttcaata taataaaaaa
54241 ttagagtttt attataggaa gaatttacca aaagaaggag gaagcaagca agtttaaact
54301 gcagcaatag ttgtccattc caacctctca aaattccctt ggagacaaaa tctctagagg
54361 caaagaagaa ctttatattg agtcaacttg ttaaaacatc tgcttttaga taagttttct
54421 tagtataaag tgacagaaac aaataagtta aactctaaga tacattccac tatattagcc
54481 taaaacactt ctgcaaaaat gaaactagga ggatattttt agaaacaact gctgaaagag
54541 atgcggtggg gagatatgca gaggagaaca gggtttctga gtcaagacac acatgacaga
54601 acagccaatc tcagggcaag ttaagggaat agtggaatga aggttcattt ttcattctca
54661 caaactaatg aaaccctgct tatcttaaac caacctgctc actggagcag ggaggacagg
54721 accagcataa aaggcagggc agagtcgact gttgcttaca ctttcttctg acataacagt
54781 gttcactagc aacctcaaac agacaccatg gtgcatctga ctcctgagga gaagactgct
54841 gtcaatgccc tgtggggcaa agtgaacgtg gatgcagttg gtggtgaggc cctgggcagg
54901 ttggtatcaa ggttataaga gaggctcaag gaggcaaatg gaaactgggc atgtgtagac
54961 agagaagact cttgggtttc tgataggcac tgactctctg tcccttgggc tgttttccta
55021 ccctcagatt actggtggtc tacccttgga cccagaggtt ctttgagtcc tttggggatc
55081 tgtcctctcc tgatgctgtt atgggcaacc ctaaggtgaa ggctcatggc aagaaggtgc
55141 taggtgcctt tagtgatggc ctggctcacc tggacaacct caagggcact ttttctcagc
55201 tgagtgagct gcactgtgac aagctgcacg tggatcctga gaacttcagg gtgagtccag
55261 gagatgcttc acttttctct ttttactttc taatcttaca ttttggttct tttacctacc
55321 tgctcttctc ccacattttt gtcattttac tatattttat catttaatgc ttctaaaatt
55381 ttgttaattt tttatttaaa tattctgcat tttttccttc ctcacaatct tgctatttta
55441 aattatttaa tatcctgtct ttctctccca accccctccc ttcatttttc cttctctaac
55501 aacaactcaa attatgcata ccagctctca cctgctaatt ctgcacttag aataatcctt
55561 ttgtctctcc acatgggtat gggagaggct ccaactcaaa gatgagaggc atagaatact
55621 gttttagagg ctataaatca ttttacaata aggaataatt ggaattttat aaattctgta
55681 gtaaatggaa tggaaaggaa agtgaatatt tgattatgaa agactaggca gttacactgg
55741 aggtggggca gaagtcgttg ctaggagaca gcccatcatc acactgatta atcaattaat
55801 ttgtatctat taatctgttt atagtaatta atttgtatat gctatataca catacaaaat
55861 taaaactaat ttggaattaa tttgtatata gtattataca gcatatatag catatatgta
55921 catatataga ctacatgcta gttaagtaca tagaggatgt gtgtgtatag atatatgtta
55981 tatgtatgca ttcatatatg tacttattta tgctgatggg aataacctgg ggatcagttt
56041 tgtctaagat ttgggcagaa aaaaatgggt gttggctcag tttctcagaa gccagtcttt
56101 atttctctgt taaccatatg catgtatctg cctacctctt ctccgcagct cttgggcaat
56161 gtgctggtgt gtgtgctggc ccgcaacttt ggcaaggaat tcaccccaca aatgcaggct
56221 gcctatcaga aggtggtggc tggtgtggct aatgccctgg ctcacaagta ccattgagat
56281 cctggactgt ttcctgataa ccataagaag accctatttc cctagattct attttctgaa
56341 cttgggaaca caatgcctac ttcaagggta tggcttctgc ctaataaaga atgttcagct
56401 caacttcctg attaatttca cttatttcat ttttttgtcc aggtgtgtaa gaaggttcct
56461 gaggctctac agatagggag cacttgttta ttttacaaag agtacatggg aaaagagaaa
56521 agcaagggaa ccgtacaagg cattaatggg tgacacttct acctccaaag agcagaaatt
56581 atcaagaact cttgatacaa agataatact ggcactgcag aggttctagg gaagacctca
56641 accctaagac atagcctcaa gggtaatagc tacgattaaa ctccaacaat tactgagaaa
56701 ataatgtgct caattaaagg cataatgatt actcaagaca atgttatgtt gtctttcttc
56761 ctccttcctt tgcctgcaca ttgtagccca taatactata ccccatcaag tgttcctgct
56821 ccaagaaata gcttcctcct cttacttgcc ccagaacatc tctgtaaaga atttcctctt
56881 atcttcccat atttcagtca agattcattg ctcacgtatt acttgtgacc tctcttgacc
56941 ccagccacaa taaacttctc tatactaccc aaaaaatctt tccaaaccct ccccgacacc
57001 atatttttat atttttctta tttatttcat gcacacacac acactccgtg ctttataagc
57061 aattctgcct attctctacc ttcttacaat gcctactgtg cctcatatta aattcatcaa
57121 tgggcagaaa gaaaatattt attcaagaaa acagtgaatg aatgaacgaa tgagtaaatg
57181 agtaaatgaa ggaatgatta ttccttgctt tagaacttct ggaattagag gacaatatta
57241 ataataccat cgcacagtgt ttctttgttg ttaatgctac aacatacaaa gaggaagcat
57301 gcagtaaaca accgaacagt tatttccttt ctgatcatag gagtaatatt tttttccttg
57361 agcacatttt tgccataggt aaaattagaa ggatttttag aactttctca gttgtataca
57421 tttttaaaaa tctgtattat atgcatgttg attaatttta aacttacttg aatacctaaa
57481 cagaatctgt tgtttccttg tgtttgaaag tgctttcaca gtaactctgt ctgtactgcc
57541 agaatatact gacaatgtgt tatagttaac tgttttgatc acaacatttt gaattgactg
57601 gcagcagaag ctctttttat atccatgtgt tttccttaag tcattataca tagtaggcat
57661 gagactcttt atactgaata agatatttag gaaccactgg tttacatatc agaagcagag
57721 ctactcaggg cattttgggg aagatcactt tcacattcct gagcataggg aagttctcat
57781 aagagtaaga tattaaaagg agatacttgt gtggtattcg aaagacagta agagagattg
57841 tagaccttat gatcttgata gggaaaacaa actacattcc tttctccaaa agtcaaaaaa
57901 aaagagcaaa tatagcttac tataccttct attcctacac cattagaagt agtcagtgag
57961 tctaggcaag atgttggccc taaaaatcca aataccagag aattcatgag aacatcacct
58021 ggatgggaca tgtgccgagc aacacaatta ctatatgcta ggcattgcta tcttcatatt
58081 gaagatgagg aggtcaagag atgaaaaaag acttggcacc ttgttgttat attaaaatta
58141 tttgttagag tagagctttt gtaagagtct aggagtgtgg gagctaaatg atgatacaca
58201 tggacacaaa gaatagatca acagacaccc aggcctactt gagggttgag ggtgggaaga
58261 gggagacgat gaaaaagaac ctattgggta ttaagttcat cactgagtga tgaaataatc
58321 tgtacatcaa gacccagtga tatgcaattt acctatataa cttgtacatg tacccccaaa
58381 tttaaaataa agttaaaaca aagtatagga atggaattaa ttcctcaaga tttggcttta
58441 attttatttg ataatttatc aaatggttgt ttttcttttc tcactatggc gttgctttat
58501 aaactatgtt cagtatgtct gaatgaaagg gtgtgtgtgt gtgtgaaaga gagggagaga
58561 ggaagggaag agaggacgta ataatgtgaa tttgagttca tgaaaatttt tcaataaaat
58621 aatttaatgt caggagaatt aagcctaata gtctcctaaa tcatccatct cttgagcttc
58681 agagcagtcc tctgaattaa tgcctacatg tttgtaaagg gtgttcagac tgaagccaag
58741 attctacctc taaagagatg caatctcaaa tttatctgaa gactgtacct ctgctctcca
58801 taaattgaca ccatggccca cttaatgagg ttaaaaaaaa gctaattctg aatgaaaatc
58861 tgagcccagt ggaggaaata ttaatgaaca aggtgcagac tgaaatataa attttctgta
58921 ataattatgc atatacttta gcaaagttct gtctatgttg actttattgc ttttggtaag
58981 aaatacaact ttttaaagtg aactaaacta tcctatttcc aaactatttt gtgtgtgtgc
59041 ggtttgtttc tatgggttct ggttttcttg gagcattttt atttcatttt aattaattaa
59101 ttctgagagc tgctgagttg tgtttactga gagattgtgt atctgcgaga gaagtctgta
59161 gcaagtagct agactgtgct tgacctagga acatatacag tagattgcta aaatgtctca
59221 cttggggaat tttagactaa acagtagagc atgtataaaa atactctagt caagtgctgc
59281 ttttgaaaca aatgataaaa ccacactccc atagatgagt gtcatgattt tcatggagga
59341 agttaatatt catcctctaa gtatacccag actagggcca ttctgatata aaacattagg
59401 acttaagaaa gattaataga ctggagtaaa ggaaatggac ctctgtctct ctcgctgtct
59461 cttttttgag gacttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttgt ggtcagtggg
59521 gctggaataa aagtagaata gacctgcacc tgctgtggca tccattcaca gagtagaagc
59581 aagctcacaa tagtgaagat gtcagtaagc ttgaatagtt tttcaggaac tttgaatgct
59641 gatttagatt tgaaactgag gctctgacca taaccaaatt tgcactattt attgcttctt
59701 gaaacttatt tgcctggtat gcctgggctt ttgatggtct tagtatagct tgcagccttg
59761 tccctgcagg gtattatggg taatagaaag aaaagtctgc gttacactct agtcacacta
59821 agtaactacc attggaaaag caacccctgc cttgaagcca ggatgatggt atctgcagca
59881 gttgccaaca caagagaagg atccatagtt catcatttaa aaaagaaaac aaaatagaaa
59941 aaggaaaact atttctgagc ataagaagtt gtagggtaag tctttaagaa ggtgacaatt
60001 tctgccaatc aggatttcaa agctcttgct ttgacaattt tggtctttca gaatactata
60061 aatataacct atattataat ttcataaagt ctgtgcattt tctttgaccc aggatatttg
60121 caaaagacat attcaaactt ccgcagaaca ctttatttca catatacatg cctcttatat
60181 cagggatgtg aaacagggtc ttgaaaactg tctaaatcta aaacaatgct aatgcaggtt
60241 taaatttaat aaaataaaat ccaaaatcta acagccaagt caaatctgta tgttttaaca
60301 tttaaaatat tttaaagacg tcttttccca ggattcaaca tgtgaaatct tttctcaggg
60361 atacacgtgt gcctagatcc tcattgcttt agttttttac agaggaatga atataaaaag
60421 aaaatactta aattttatcc ctcttacctc tataatcata cataggcata attttttaac
60481 ctaggctcca gatagccata gaagaaccaa acactttctg cgtgtgtgag aataatcaga
60541 gtgagatttt ttcacaagta cctgatgagg gttgagacag gtagaaaaag tgagagatct
60601 ctatttattt agcaataata gagaaagcat ttaagagaat aaagcaatgg aaataagaaa
60661 tttgtaaatt tccttctgat aactagaaat agaggatcca gtttcttttg gttaacctaa
60721 attttatttc attttattgt tttattttat tttattttat tttattttgt gtaatcgtag
60781 tttcagagtg ttagagctga aaggaagaag taggagaaac atgcaaagta aaagtataac
60841 actttcctta ctaaaccgac tgggtttcca ggtaggggca ggattcagga tgactgacag
60901 ggcccttagg gaacactgag accctacgct gacctcataa atgcttgcta cctttgctgt
60961 tttaattaca tcttttaata gcaggaagca gaactctgca cttcaaaagt ttttcctcac
61021 ctgaggagtt aatttagtac aaggggaaaa agtacagggg gatgggagaa aggcgatcac
61081 gttgggaagc tatagagaaa gaagagtaaa ttttagtaaa ggaggtttaa acaaacaaaa
61141 tataaagaga aataggaact tgaatcaagg aaatgatttt aaaacgcagt attcttagtg
61201 gactagagga aaaaaataat ctgagccaag tagaagacct tttcccctcc tacccctact
61261 ttctaagtca cagaggcttt ttgttccccc agacactctt gcagattagt ccaggcagaa
61321 acagttagat gtccccagtt aacctcctat ttgacaccac tgattacccc attgatagtc
61381 acactttggg ttgtaagtga ctttttattt atttgtattt ttgactgcat taagaggtct
61441 ctagtttttt atctcttgtt tcccaaaacc taataagtaa ctaatgcaca gagcacattg
61501 atttgtattt attctatttt tagacataat ttattagcat gcatgagcaa attaagaaaa
61561 acaacaacaa atgaatgcat atatatgtat atgtatgtgt gtatatatac acatatatat
61621 atatattttt tttcttttct taccagaagg ttttaatcca aataaggaga agatatgctt
61681 agaactgagg tagagttttc atccattctg tcctgtaagt attttgcata ttctggagac
61741 gcaggaagag atccatctac atatcccaaa gctgaattat ggtagacaaa gctcttccac
61801 ttttagtgca tcaatttctt atttgtgtaa taagaaaatt gggaaaacga tcttcaatat
61861 gcttaccaag ctgtgattcc aaatattacg taaatacact tgcaaaggag gatgttttta
61921 gtagcaattt gtactgatgg tatggggcca agagatatat cttagaggga gggctgaggg
61981 tttgaagtcc aactcctaag ccagtgccag aagagccaag gacaggtacg gctgtcatca
62041 cttagacctc accctgtgga gccacaccct agggttggcc aatctactcc caggagcagg
62101 gagggcagga gccagggctg ggcataaaag tcagggcaga gccatctatt gcttacattt
62161 gcttctgaca caactgtgtt cactagcaac ctcaaacaga caccatggtg cacctgactc
62221 ctgaggagaa gtctgccgtt actgccctgt ggggcaaggt gaacgtggat gaagttggtg
62281 gtgaggccct gggcaggttg gtatcaaggt tacaagacag gtttaaggag accaatagaa
62341 actgggcatg tggagacaga gaagactctt gggtttctga taggcactga ctctctctgc
62401 ctattggtct attttcccac ccttaggctg ctggtggtct acccttggac ccagaggttc
62461 tttgagtcct ttggggatct gtccactcct gatgctgtta tgggcaaccc taaggtgaag
62521 gctcatggca agaaagtgct cggtgccttt agtgatggcc tggctcacct ggacaacctc
62581 aagggcacct ttgccacact gagtgagctg cactgtgaca agctgcacgt ggatcctgag
62641 aacttcaggg tgagtctatg ggacccttga tgttttcttt ccccttcttt tctatggtta
62701 agttcatgtc ataggaaggg gagaagtaac agggtacagt ttagaatggg aaacagacga
62761 atgattgcat cagtgtggaa gtctcaggat cgttttagtt tcttttattt gctgttcata
62821 acaattgttt tcttttgttt aattcttgct ttcttttttt ttcttctccg caatttttac
62881 tattatactt aatgccttaa cattgtgtat aacaaaagga aatatctctg agatacatta
62941 agtaacttaa aaaaaaactt tacacagtct gcctagtaca ttactatttg gaatatatgt
63001 gtgcttattt gcatattcat aatctcccta ctttattttc ttttattttt aattgataca
63061 taatcattat acatatttat gggttaaagt gtaatgtttt aatatgtgta cacatattga
63121 ccaaatcagg gtaattttgc atttgtaatt ttaaaaaatg ctttcttctt ttaatatact
63181 tttttgttta tcttatttct aatactttcc ctaatctctt tctttcaggg caataatgat
63241 acaatgtatc atgcctcttt gcaccattct aaagaataac agtgataatt tctgggttaa
63301 ggcaatagca atatttctgc atataaatat ttctgcatat aaattgtaac tgatgtaaga
63361 ggtttcatat tgctaatagc agctacaatc cagctaccat tctgctttta ttttatggtt
63421 gggataaggc tggattattc tgagtccaag ctaggccctt ttgctaatca tgttcatacc
63481 tcttatcttc ctcccacagc tcctgggcaa cgtgctggtc tgtgtgctgg cccatcactt
63541 tggcaaagaa ttcaccccac cagtgcaggc tgcctatcag aaagtggtgg ctggtgtggc
63601 taatgccctg gcccacaagt atcactaagc tcgctttctt gctgtccaat ttctattaaa
63661 ggttcctttg ttccctaagt ccaactacta aactggggga tattatgaag ggccttgagc
63721 atctggattc tgcctaataa aaaacattta ttttcattgc aatgatgtat ttaaattatt
63781 tctgaatatt ttactaaaaa gggaatgtgg gaggtcagtg catttaaaac ataaagaaat
63841 gaagagctag ttcaaacctt gggaaaatac actatatctt aaactccatg aaagaaggtg
63901 aggctgcaaa cagctaatgc acattggcaa cagccctgat gcctatgcct tattcatccc
63961 tcagaaaagg attcaagtag aggcttgatt tggaggttaa agttttgcta tgctgtattt
64021 tacattactt attgttttag ctgtcctcat gaatgtcttt tcactaccca tttgcttatc
64081 ctgcatctct cagccttgac tccactcagt tctcttgctt agagatacca cctttcccct
64141 gaagtgttcc ttccatgttt tacggcgaga tggtttctcc tcgcctggcc actcagcctt
64201 agttgtctct gttgtcttat agaggtctac ttgaagaagg aaaaacaggg ggcatggttt
64261 gactgtcctg tgagcccttc ttccctgcct cccccactca cagtgacccg gaatctgcag
64321 tgctagtctc ccggaactat cactctttca cagtctgctt tggaaggact gggcttagta
64381 tgaaaagtta ggactgagaa gaatttgaaa gggggctttt tgtagcttga tattcactac
64441 tgtcttatta ccctatcata ggcccacccc aaatggaagt cccattcttc ctcaggatgt
64501 ttaagattag cattcaggaa gagatcagag gtctgctggc tcccttatca tgtcccttat
64561 ggtgcttctg gctctgcagt tattagcata gtgttaccat caaccacctt aacttcattt
64621 ttcttattca atacctaggt aggtagatgc tagattctgg aaataaaata tgagtctcaa
64681 gtggtccttg tcctctctcc cagtcaaatt ctgaatctag ttggcaagat tctgaaatca
64741 aggcatataa tcagtaataa gtgatgatag aagggtatat agaagaattt tattatatga
64801 gagggtgaaa cctaaaatga aatgaaatca gacccttgtc ttacaccata aacaaaaata
64861 aatttgaatg ggttaaagaa ttaaactaag acctaaaacc ataaaaattt ttaaagaaat
64921 caaaagaaga aaattctaat attcatgttg cagccgtttt ttgaatttga tatgagaagc
64981 aaaggcaaca aaaggaaaaa taaagaagtg aggctacatc aaactaaaaa atttccacac
65041 aaaaaagaaa acaatgaaca aatgaaaggt gaaccatgaa atggcatatt tgcaaaccaa
65101 atatttctta aatattttgg ttaatatcca aaatatataa gaaacacaga tgattcaata
65161 acaaacaaaa aattaaaaat aggaaaataa aaaaattaaa aagaagaaaa tcctgccatt
65221 tatgcgagaa ttgatgaacc tggaggatgt aaaactaaga aaaataagcc tgacacaaaa
65281 agacaaatac tacacaacct tgctcatatg tgaaacataa aaaagtcact ctcatggaaa
65341 cagacagtag aggtatggtt tccaggggtt gggggtggga gaatcaggaa actattactc
65401 aaagggtata aaatttcagt tatgtgggat gaataaattc tagatatcta atgtacagca
65461 tcgtgactgt agttaattgt actgtaagta tatttaaaat ttgcaaagag agtagatttt
65521 tttgtttttt tagatggagt tttgctcttg ttgtccaggc tggagtgcaa tggcaagatc
65581 ttggctcact gcaacctccg cctcctgggt tcaagcaaat ctcctgcctc agcctcccga
65641 gtagctggga ttacaggcat gcgacaccat gcccagctaa ttttgtattt ttagtagaga
65701 cggggtttct ccatgttggt caggctgatc cgcctcctcg gccaccaaag ggctgggatt
65761 acaggcgtga ccaccgggcc tggccgagag tagatcttaa aagcatttac cacaagaaaa
65821 aggtaactat gtgagataat gggtatgtta attagcttga ttgtggtaat catttcacaa
65881 ggtatacata tattaaaaca tcatgttgta caccttaaat atatacaatt tttatttgtg
65941 aatgatacct caataaagtt gaagaataat aaaaaagaat agacatcaca tgaattaaaa
66001 aactaaaaaa taaaaaaatg catcttgatg attagaattg cattcttgat ttttcagata
66061 caaatatcca tttgactgtt tactcttttc caaaacaata caataaattt tagcacttta
66121 tcttcatttt ccccttccca atctataatt ttatatatat atattttaga tattttgtat
66181 agttttactc cctagatttt ctagtgttat tattaaatag tgaagaaatg tttacactta
66241 tgtacaaaat gttttgcatg cttttcttca tttctaacat tctctctaag tttattctat
66301 tttttcctga ttatccttaa tattatctct ttctgctgga aatatattgt tacttttggt
66361 ttatctaaaa atggcttcat tttcttcatt ctaaaatcat gttaaattaa taccactcat
66421 gtgtaagtaa gatagtggaa taaatagaaa tccaaaaact aaatctcaca aaatataata
66481 atgtgatata taaaaatata gcttttaaat ttagcttgga aataaaaaac aaacagtaat
66541 tgaacaacta tactttttga aaagagtaaa gtgaaatgct taactgcata taccacaatc
66601 gattacacaa ttaggtgtga aggtaaaatt cagtcacgaa aaaactagaa taaaaatatg
66661 ggaagacatg tatataatct tagagataac agtgttattt aattatcaac ccaaagtaga
66721 aactatcaag ggagaaataa attcagtcaa caataaaagc atttaagaag ttattctagg
66781 ctgggagcgg tggctcacac ctgcaattgc agcactttgg gaggcctaga caggcggatc
66841 acgacgtcag gagttcaaga tcagcctggc caacatagtg aaacctcatc gctactaaaa
66901 atataaaaac ttagcctggc gtggtggcag gcatgtgtaa tcccagcaat ttgggaggct
66961 gaggcaggag aatcgcttga tcctgggagg cagaggttgc agtgagccaa gattgtgcca
67021 ctgcattcca gcccaggtga cagcatgaga ctccgtcaca aaaaaaaaag aaaaaaaagg
67081 gggggggggg cggtggagcc aagatgaccg aataggaaca gctccagtct atagctccca
67141 tcgtgagtga cgcagaagac gggtgatttc tgcatttcca actgaggtac caggttcatc
67201 tcacagggaa gtgccaggca gtgggtgcag gacagtagtg cagtgcactg tgcatgagcc
67261 gaagcagggc gaggcatcac ctcacccggg aagcacaagg ggtcagggaa ttccctttcc
67321 tagtcaaaga aaagggtgac agatggcacc tggaaaatcg ggtcactccc gccctaatac
67381 tgcgctcttc caacaagctt aacaaatggc acaccaggag attatatccc atgcctggct
67441 cagagggtcc tacgcccatg gagcctcgct cattgctagc acagcagtct gaggtcaaac
67501 tgcaaggtgg cagtgaggct gggggagggg tgcccaccat tgtccaggct tgagcaggta
67561 aacaaagccg cctggaagct cgaactgggt ggagcccacc acagctcaag gaggcctgcc
67621 tgcctctgta ggctccacct ctaggggcag ggcacagaca aacaaaagac aacaagaacc
67681 tctgcagact taaatgtccc tgtctgacag ctttgaagag agtagtggtt ctcccagcac
67741 atagcttcag atctgagaac aggcagactg cctcctcaag tgggtccctg acccccgagt
67801 agcctaactg ggaggcatcc cccagtaggg cggactgaca cctcacatgg ctggtactcc
67861 tctaagacaa aacttccaga ggaatgatca ggcagcagca tttgcggttc accaatatcc
67921 actgttctgc agccaccgct gctgataccc aggaaaacag catctggagt ggacctccag
67981 taaactccaa cagacctgca gctgagggtc ctgactgtta gaaggaaaac taacaaacag
68041 aaaggacatc cacaccaaaa acccatctgt acatcaccat catcaaagac caaaggtaga
68101 taaaaccata aagatgggga aaaagcagag cagaaaaact ggacactcta aaaatgagag
68161 tgcctctcct tctccaaagt aacgcagctc ctcaccagca atggaacaaa gctgggcaga
68221 gaatgacttt gacgagttga gagaggaagg cttcagaaga tcaaactact ccaagctaaa
68281 ggaggaagtt cgaacaaacg gcaaagaagt aaaaaacttt gaaaaaaaat tagatgaatg
68341 gataactaga ataaccaatg cacagaagtc cttaaaggac ctgatggagc tgaaaaccaa
68401 ggcaggagaa ctacgtgaca aatacacaag cctcagtaac cgatgagatc aactggaaga
68461 aagggtatca atgacggaag atgaaatgaa tgaaatgaag catgaagaga agtttagaga
68521 aaaaagaata aaaagaaacg aacaaagcct ccaagaaata tgggactatg tgaaaagacc
68581 aaatctacat ctaattggtg tagctgaaag tgatggggag aatggaacca agttggaaaa
68641 cactctgcag gatattatcc aggagaactt ccccaatcta gcaaggcagc ccaaattcac
68701 attcaggaaa tacagagaac gccacaaaga tactcctaga gaaaagcaac tccaagacac
68761 ataactgaca gattcaccaa agttgaaatg aaggaaaaaa tgttaagggc agccagagag
68821 aaaggtcggg ttacccacaa agggaagccc atcagactaa cagctgatct atcggcagaa
68881 actctacaag ccagaagaaa gtgggggcca atattcaaca ttgttaaaga aaagaatttt
68941 cggcccagaa tttcatatcc agccaaacta agcttcataa gcattggaga aataaaatcc
69001 tttacagaca agcaaatgct gagagatttt gtcaccacca ggcctgccct acaagagctc
69061 ctgaaggaag cactaaacat ggaaaggaac aactagtatc agccactgca aaaacatgcc
69121 aaattgtaaa cgaccatcaa ggctaggaag aaactgcatc aaggagcaaa ataaccagct
69181 aacatcataa tgacaggatc aaattcatac ataacaatac tcaccttaaa tgtaaatagg
69241 ctaaatgctc caattaaaag acacagactg gcaaattgga taaggagtca agacccatct
69301 gtcgttatgt attcaggaaa cccatctcac gtgcagagac acacataggc tcgaaataaa
69361 aggatggagg aatatctacc aagcaaatgg aaaacaaaaa aaggcagggg ttgcaatcct
69421 agtctctgat aaaacagatt ttaaaccaac aaagatcaaa agagacaaag aaggccatta
69481 cataatggca aagggatcta ttcaagaaga agaactaact atactaaata tatatgcacc
69541 caatacagga gcacccagat tcataaaaca agtcctgagt gacctacaaa gagacttaga
69601 tgcccacaca ataataatgg gagactttaa caccccactg tcaacattag acagatcaac
69661 gagacagaaa gttaacaagg atatccagga attggactca gctctgcacc aagcagacct
69721 aatagacatc tacagaactc tccaccccaa atcaacagaa tatacattct tttcagcacc
69781 acaccacacc tattccaaaa ctgaccacat agttggaagt aaagctctcc tcagcaaatg
69841 taaaagaaca gaaactataa caaactgtct ctcagaccac agtgcaatca aactagaact
69901 caggattaag aaactcactc aaaaccactc agctacatgg aaactgaaca gcctgctcct
69961 gaatgactac tgggtacata acaaaatgaa ggcagaaata aagatgttct ttgaaacaac
70021 gagaacaaag acacaacaca ccagaatctc tgagacacat tcaaagcagt gtgtagaggg
70081 aaatttatag cactaaatgc ccacaaggga aagcaggaaa gatctaaaat tgacacccta
70141 acatcacaat taaaaaacta gagaagcagg agcaaacaca ttcaaaagct aacagaagac
70201 aagaaataac taagatcaga gcagaagtga agaagataga gacacaaaaa acccttcaaa
70261 aaaatcaatg aatccagaag ctgttttttt gaaaagatca acaaaattga tagactgcta
70321 gcaagactaa taaagaagaa aggggagaag aatcaaatag acgcaataaa aaatgacacg
70381 gggtatcacc actgatccca cagaaataca aactaccgtc agagaatact ataaacacct
70441 ctacgcaaat aaactagaaa atctagaaga aatggataaa ttcctcgaca catacactct
70501 gccaagacta aaccaggaag aagttgtatc tctgaataga ccaataacag gctctgaaat
70561 tgaggcaata attaatagct tatcaaccaa aaaaagtccg ggaccagtag gattcatagc
70621 cgaattctac cagaggtaca aggaggagct ggtaccattc cttctgaaac tattccaatc
70681 aatagaaaaa gagggaatcc tccctaactc attttatgag gccagcatca tcctgatacc
70741 aaagcctgac agagacacaa caaaaaaaga gaatgttaca ccaatatcct tgatgaacat
70801 cgatgcaaaa atcctcaata aaatactggc aaactgaatc cagcagcaca tcaaaaagct
70861 tatcctccat gatcaagtgg gcttcatccc tgccatgcaa ggctggttca acatacgaaa
70921 tcaataaaca taatccagca tataaacaga accaaagaca caaaccatat gattatctca
70981 atagatgcag aaaaggcctt tgacaaaatt caacaatgct tcatgctaaa aactctcaat
71041 aaattaggta ttgatgggac atatctcaaa ataataagag ctatctatga caaacccaca
71101 gccaatatca tactgagtgg acaaaaactg gaagcattcc ctttgaaaac tggcacaagg
71161 cagggatgcc ctctctcacc actcctattc aacatagtgt tggaagttct ggccagggca
71221 atcaggcagg agaaggaaat aaagggcatt caattaggaa aagaggaagg tgaaattgtc
71281 cctgtttgca gatgacatga ttgtatatct agaaaacccc attgtctcag cccaaaatct
71341 ccttaagctg ataagcaact tcagcaaagt ctcaggatat aaaatcagtg tgcaaaaatc
71401 acaagtattc ctatgcacca ataacagaca aacagagagc caaatcatga gtgaactccc
71461 attcacaatt gcttcaaaga gaataaaata cctaggaatc caacttacaa gggatgtgaa
71521 ggacctcttc aaggagaact acaaaccact gctcaatgaa ataaaagagg atacaaacaa
71581 atggaagaac attccatgct tatgggtagg aagaatcata tcgtgaaaat ggtcatactg
71641 cccaaggtaa tttatagatt caatgccatc cccatcaagc taccaatgac tttcttcaca
71701 gaactggaaa aaactacttt aaagttcata tggaatcaaa aaagagccca catcaccaag
71761 gcaatcctaa gccaaaagaa caaagctgga ggcatcacgc tacctgactt caaactatac
71821 tacaatgcta cggtaaccaa aacagcatgg tactggtacc aaaacagaga tctagaccaa
71881 tggaacagaa cagagccctc agaaataatg ccgcatatct acaactatcc gatctttgac
71941 aaacctgaga gaaacaagca atggggaaag gattccctat ttaataaatg gtgctgggaa
72001 aactggctag ccatatgtag aaagctgaaa ctggatcctt ccttacacct tatacaaaaa
72061 ttaattcaag atggattaaa gacttaaaca ttagacctaa aaccataaaa accctagaaa
72121 aaaacctagg caataccatt caggacatag gcatgggcaa ggacttcatg tctaaaacac
72181 caaaacgaat ggcaacaaaa gacaaaatgg acaaacggga tctaattaaa ctaaagagct
72241 tctgcacagc taaagaaact accatcagag tgaacaggca acctacaaaa tgggagaaaa
72301 tttttgcaat ctactcatct gacaaagggc taatatccag aatctacaat gaactcaaac
72361 aaatttacaa gaaaaaacaa acaaccccat caaaaagtgg gcaaaggata tgaacagaca
72421 cttctcaaaa gaagacattt atgtaatcaa aaaacacatg aaaaaatgct catcatcact
72481 agccatcaga gaaatgcaaa tcaaaaccac aatgagatac catctcacac cagttagaat
72541 ggcgatcatt aaaaagtcag gaaacaacag gtgctggaga ggatgtggag aaacaggaac
72601 aacttttaca ctgttggtgg gactgtaaac tagttcaacc attgcggaag tcagtgtggc
72661 aattcctcag gaatctagaa ctagaaatac catttgaccc agccatccca ttactgggta
72721 gatacccaaa ggattataaa tcatgctgct ataaagacac atgcacacgt atgtttattg
72781 cagcactatt cacaatagca aagacttgga accaacccaa atgtccaaca acgatagatt
72841 ggattaagaa aatgtggcac atatacacca tggaatacta tgcagccata aaaaatgatg
72901 agttcatgtc ctttgtaggg acatggatga agctggaaac tatcattctc agcaaactat
72961 cacaaggaca ataaaccaaa caccgcatgt tctcactcat aggtgggaat tgaacaatga
73021 gaacacatgg acacatgaag aggaacatca cactctgggg actgttatgg ggtggggggc
73081 aggggcaggg atagcactag gagatatacc taatgctaaa tgacgagtta atgggtgcag
73141 cacaccaaca tggcacatgt atacatatat aacaaacctg ccgttgtgca catgtaccct
73201 aaaacttgaa gtataataat aaaaaaaagt tatcctatta aaactgatct cacacatccg
73261 tagagccatt atcaagtctt tctctttgaa acagacagaa atttagtgtt ttctcagtca
73321 gttaac
//
© Genebank 1991